Cooperative contributions of structural and functional connectivity to successful memory in aging.
Repository Usage Stats
Understanding the precise relation between functional connectivity and structural (white matter) connectivity and how these relationships account for cognitive changes in older adults are major challenges for neuroscience. We investigate these issues using an approach in which structural equation modeling (SEM) is employed to integrate functional and structural connectivity data from younger and older adults (n = 62), analyzed with a common framework based on regions connected by canonical tract groups (CTGs). CTGs (e.g., uncinate fasciculus) serve as a common currency between functional and structural connectivity matrices, and ensure equivalent sparsity in connectome information. We used this approach to investigate the neural mechanisms supporting memory for items and memory for associations, and how they are affected by healthy aging. We found that different structural and functional CTGs made independent contributions to source and item memory performance, suggesting that both forms of connectivity underlie age-related differences in specific forms of memory. Furthermore, the relationship between functional and structural connectivity was best explained by a general relationship between latent constructs-a relationship absent in any specific CTG group. These results provide insights into the relationship between structural and functional connectivity patterns, and elucidate their relative contribution to age-related differences in source memory performance.
Published Version (Please cite this version)10.1162/netn_a_00064
Publication InfoDavis, Simon; Cabeza, Roberto; Szymanski, Amanda; Boms, Homa; & Fink, Thomas (2019). Cooperative contributions of structural and functional connectivity to successful memory in aging. Network neuroscience (Cambridge, Mass.), 3(1). pp. 173-194. 10.1162/netn_a_00064. Retrieved from https://hdl.handle.net/10161/19047.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young and older adults using fMRI. We have three main lines of research: First, we distinguish the neural correlates of various episodic memory processes. For example, we have compared encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false memory, and emotional vs. nonemotional memory. We are particularly interested in the contribution of prefrontal cortex (PFC) and medial temporal lobe (M
Assistant Professor in Neurology
My research centers around the use of structural and functional imaging measures to study the shifts in network architecture in the aging brain. I am specifically interested in changes in how changes in structural and functional connectivity associated with aging impact the semantic retrieval of word or fact knowledge. Currently this involves asking why older adults have particular difficulty in certain kinds of semantic retrieval, despite the fact that vocabularies and knowledge stores typic
Alphabetical list of authors with Scholars@Duke profiles.