Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
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Published Version (Please cite this version)10.1038/s41467-019-11375-7
Publication InfoHolley, Christopher; Elliott, Brittany A; Ho, Hsiang-Ting; Ranganathan, Srivathsan V; Vangaveti, Sweta; Ilkayeva, Olga; ... Agris, Paul F (2019). Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo. Nature Communications, 10(1). 10.1038/s41467-019-11375-7. Retrieved from https://hdl.handle.net/10161/19148.
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Assistant Professor of Medicine
The Holley Laboratory is focused on the role of non-coding RNA (ncRNA) in cardiovascular health and disease, with a special emphasis on snoRNA (small nucleolar RNA). snoRNAs are canonically known to guide the chemical modification of other RNAs, with ribosomal RNA being the primary target. Dr. Holley’s research has helped to uncover a novel biologic role for the Rpl13a snoRNAs in the regulation of reactive oxygen species (ROS) and oxidative stress. These four