A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data.
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INTRODUCTION:Characterizing progression in Alzheimer's disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression-free survival in patients with mild cognitive impairment. METHODS:The information contained in multiple longitudinal markers was extracted using multivariate functional principal components analysis and used as predictors in the Cox regression models. Cross-validation was used for selecting the best model based on Alzheimer's Disease Neuroimaging Initiative-1. External validation was conducted on Alzheimer's Disease Neuroimaging Initiative-2. RESULTS:Model comparison yielded a prognostic index computed as the weighted combination of historical information of five neurocognitive longitudinal markers that are routinely collected in observational studies. The comprehensive validity analysis provided solid evidence of the usefulness of the model for predicting Alzheimer's disease progression. DISCUSSION:The prognostic model was improved by incorporating multiple longitudinal markers. It is useful for monitoring disease and identifying patients for clinical trial recruitment.
Published Version (Please cite this version)10.1016/j.jalz.2017.11.004
Publication InfoLutz, Michael; Luo, Sheng; O'Brien, Richard; & Li, Kan (2018). A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data. Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(5). pp. 644-651. 10.1016/j.jalz.2017.11.004. Retrieved from https://hdl.handle.net/10161/19150.
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Professor of Biostatistics & Bioinformatics
Assistant Professor of Neurology
Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.
Disque D. Deane University Professor of Neurology
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