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Evaluation of dosimetric uncertainty caused by MR geometric distortion in MRI-based liver SBRT treatment planning.

dc.contributor.author Cai, Jing
dc.contributor.author Yin, Fang-Fang
dc.contributor.author Han, Silu
dc.date.accessioned 2019-10-01T14:11:02Z
dc.date.available 2019-10-01T14:11:02Z
dc.date.issued 2019-02
dc.identifier.issn 1526-9914
dc.identifier.issn 1526-9914
dc.identifier.uri https://hdl.handle.net/10161/19371
dc.description.abstract PURPOSE:MRI-based treatment planning is a promising technique for liver stereotactic-body radiation therapy (SBRT) treatment planning to improve target volume delineation and reduce radiation dose to normal tissues. MR geometric distortion, however, is a source of potential error in MRI-based treatment planning. The aim of this study is to investigate dosimetric uncertainties caused by MRI geometric distortion in MRI-based treatment planning for liver SBRT. MATERIALS AND METHODS:The study was conducted using computer simulations. 3D MR geometric distortion was simulated using measured data in the literature. Planning MR images with distortions were generated by integrating the simulated 3D MR geometric distortion onto planning CT images. MRI-based treatment plans were then generated on the planning MR images with two dose calculation methods: (1) using original CT numbers; and (2) using organ-specific assigned CT numbers. Dosimetric uncertainties of various dose-volume-histogram parameters were determined as their differences between the simulated MRI-based plans and the original clinical CT-based plans for five liver SBRT cases. RESULTS:The average simulated distortion for the five liver SBRT cases was 2.77 mm. In the case of using original CT numbers for dose calculation, the average dose uncertainties for target volumes and critical structures were <0.5 Gy, and the average target volume percentage at prescription dose uncertainties was 0.97%. In the case of using assigned CT numbers, the average dose uncertainties for target volumes and critical structures were <1.0 Gy, and the average target volume percentage at prescription dose uncertainties was 2.02%. CONCLUSIONS:Dosimetric uncertainties caused by MR geometric distortion in MRI-based liver SBRT treatment planning was generally small (<1 Gy) when the distortion is 3 mm.
dc.language eng
dc.publisher Wiley
dc.relation.ispartof Journal of applied clinical medical physics
dc.relation.isversionof 10.1002/acm2.12520
dc.subject Humans
dc.subject Liver Neoplasms
dc.subject Magnetic Resonance Imaging
dc.subject Radiosurgery
dc.subject Radiotherapy Dosage
dc.subject Radiotherapy Planning, Computer-Assisted
dc.subject Uncertainty
dc.subject Phantoms, Imaging
dc.subject Image Processing, Computer-Assisted
dc.subject Radiotherapy, Intensity-Modulated
dc.subject Organs at Risk
dc.title Evaluation of dosimetric uncertainty caused by MR geometric distortion in MRI-based liver SBRT treatment planning.
dc.type Journal article
duke.contributor.id Cai, Jing|0512503
duke.contributor.id Yin, Fang-Fang|0334491
dc.date.updated 2019-10-01T14:11:01Z
pubs.begin-page 43
pubs.end-page 50
pubs.issue 2
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Radiation Oncology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke Kunshan University Faculty
pubs.organisational-group Duke Kunshan University
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.publication-status Published
pubs.volume 20
duke.contributor.orcid Yin, Fang-Fang|0000-0002-2025-4740


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