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    The investigation on the location effect of external markers in respiratory-gated radiotherapy.

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    Date
    2008-04-16
    Authors
    Yin, Fang-Fang
    Yan, Hui
    Zhu, Guopei
    Yang, James
    Lu, Mei
    Ajlouni, Munther
    Kim, Jae Ho
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    Abstract
    PURPOSE:To investigate the effect of the marker placement on the correlation relationship between the motions of external markers and the internal target under different breathing patterns for several lung cancer patients. METHOD AND MATERIAL:To monitor and record simultaneous motions of internal target and associated surrogate markers during respiratory gated radiotherapy, an infrared camera system synchronized with a medical simulator was installed in our institute. Multiple external markers were placed on the patients' chest wall with proper geometrical arrangement in closely monitoring the motion of skin near tumor. The motion signals of three breathing sessions (free breathing, breath-holding, and free breathing after breath-holding) were recorded and the quality of correlation between them was analyzed. For a single marker motion, its correlation with the internal target was analyzed using cross-covariance function. For the multiple markers, their correlation with the internal target was analyzed based on additive model. RESULT:Seven patients undergoing radiotherapy with right upper or middle lobe lesions were enrolled in this study. Statistic analysis based on the internal-external motion signals shows that the effect of marker location on the quality of its correlation with the internal target is varied from patient to patient. There was no specific marker location where consistently demonstrated superior quality of correlation with the internal target motion over three breathing sessions for all patients. As the composite surrogate signal which was generated from the motions of multiple external markers was used to correlate the internal target motion, significant improvement of the quality of correlation was achieved. CONCLUSION:The correlation of external marker to the internal target could be influenced by several factors such as patient population, marker locations, and breathing patterns, considerably. The quality of correlation and predictability to the internal target furnished by a single external marker is inferior to that of the composite signal generated from multiple external markers. The use of composite signal shows great potential in improving the predictability of internal target motion and presents an effective way to track tumor more accurately.
    Type
    Journal article
    Subject
    Humans
    Adenocarcinoma
    Carcinoma, Squamous Cell
    Breast Neoplasms
    Lung Neoplasms
    Radiotherapy Planning, Computer-Assisted
    Respiration
    Movement
    Aged
    Middle Aged
    Female
    Permalink
    https://hdl.handle.net/10161/19394
    Published Version (Please cite this version)
    10.1120/jacmp.v9i2.2758
    Publication Info
    Yin, Fang-Fang; Yan, Hui; Zhu, Guopei; Yang, James; Lu, Mei; Ajlouni, Munther; & Kim, Jae Ho (2008). The investigation on the location effect of external markers in respiratory-gated radiotherapy. Journal of applied clinical medical physics, 9(2). pp. 2758. 10.1120/jacmp.v9i2.2758. Retrieved from https://hdl.handle.net/10161/19394.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Yin

    Fang-Fang Yin

    Professor in Radiation Oncology
    Stereotactic radiosurgery, Stereotactic body radiation therapy, treatment planning optimization, knowledge guided radiation therapy, intensity-modulated radiation therapy, image-guided radiation therapy, oncological imaging and informatics
    Open Access

    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

    Rights for Collection: Scholarly Articles

     

     

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