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The investigation on the location effect of external markers in respiratory-gated radiotherapy.

dc.contributor.author Yan, Hui
dc.contributor.author Zhu, Guopei
dc.contributor.author Yang, James
dc.contributor.author Lu, Mei
dc.contributor.author Ajlouni, Munther
dc.contributor.author Kim, Jae Ho
dc.contributor.author Yin, Fang-Fang
dc.date.accessioned 2019-10-04T15:45:35Z
dc.date.available 2019-10-04T15:45:35Z
dc.date.issued 2008-04-16
dc.identifier.issn 1526-9914
dc.identifier.issn 1526-9914
dc.identifier.uri https://hdl.handle.net/10161/19394
dc.description.abstract PURPOSE:To investigate the effect of the marker placement on the correlation relationship between the motions of external markers and the internal target under different breathing patterns for several lung cancer patients. METHOD AND MATERIAL:To monitor and record simultaneous motions of internal target and associated surrogate markers during respiratory gated radiotherapy, an infrared camera system synchronized with a medical simulator was installed in our institute. Multiple external markers were placed on the patients' chest wall with proper geometrical arrangement in closely monitoring the motion of skin near tumor. The motion signals of three breathing sessions (free breathing, breath-holding, and free breathing after breath-holding) were recorded and the quality of correlation between them was analyzed. For a single marker motion, its correlation with the internal target was analyzed using cross-covariance function. For the multiple markers, their correlation with the internal target was analyzed based on additive model. RESULT:Seven patients undergoing radiotherapy with right upper or middle lobe lesions were enrolled in this study. Statistic analysis based on the internal-external motion signals shows that the effect of marker location on the quality of its correlation with the internal target is varied from patient to patient. There was no specific marker location where consistently demonstrated superior quality of correlation with the internal target motion over three breathing sessions for all patients. As the composite surrogate signal which was generated from the motions of multiple external markers was used to correlate the internal target motion, significant improvement of the quality of correlation was achieved. CONCLUSION:The correlation of external marker to the internal target could be influenced by several factors such as patient population, marker locations, and breathing patterns, considerably. The quality of correlation and predictability to the internal target furnished by a single external marker is inferior to that of the composite signal generated from multiple external markers. The use of composite signal shows great potential in improving the predictability of internal target motion and presents an effective way to track tumor more accurately.
dc.language eng
dc.relation.ispartof Journal of applied clinical medical physics
dc.relation.isversionof 10.1120/jacmp.v9i2.2758
dc.subject Humans
dc.subject Adenocarcinoma
dc.subject Carcinoma, Squamous Cell
dc.subject Breast Neoplasms
dc.subject Lung Neoplasms
dc.subject Radiotherapy Planning, Computer-Assisted
dc.subject Respiration
dc.subject Movement
dc.subject Aged
dc.subject Middle Aged
dc.subject Female
dc.title The investigation on the location effect of external markers in respiratory-gated radiotherapy.
dc.type Journal article
duke.contributor.id Yan, Hui|0337692
duke.contributor.id Yin, Fang-Fang|0334491
dc.date.updated 2019-10-04T15:45:33Z
pubs.begin-page 2758
pubs.issue 2
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Kunshan University Faculty
pubs.organisational-group Duke Kunshan University
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Radiation Oncology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Faculty
pubs.publication-status Published
pubs.volume 9
duke.contributor.orcid Yin, Fang-Fang|0000-0002-2025-4740


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