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BigSMILES: A Structurally-Based Line Notation for Describing Macromolecules.

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Date
2019-09-12
Authors
Lin, Tzyy-Shyang
Coley, Connor W
Mochigase, Hidenobu
Beech, Haley K
Wang, Wencong
Wang, Zi
Woods, Eliot
Craig, Stephen L
Johnson, Jeremiah A
Kalow, Julia A
Jensen, Klavs F
Olsen, Bradley D
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(12 total)
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Abstract
Having a compact yet robust structurally based identifier or representation system is a key enabling factor for efficient sharing and dissemination of research results within the chemistry community, and such systems lay down the essential foundations for future informatics and data-driven research. While substantial advances have been made for small molecules, the polymer community has struggled in coming up with an efficient representation system. This is because, unlike other disciplines in chemistry, the basic premise that each distinct chemical species corresponds to a well-defined chemical structure does not hold for polymers. Polymers are intrinsically stochastic molecules that are often ensembles with a distribution of chemical structures. This difficulty limits the applicability of all deterministic representations developed for small molecules. In this work, a new representation system that is capable of handling the stochastic nature of polymers is proposed. The new system is based on the popular "simplified molecular-input line-entry system" (SMILES), and it aims to provide representations that can be used as indexing identifiers for entries in polymer databases. As a pilot test, the entries of the standard data set of the glass transition temperature of linear polymers (Bicerano, 2002) were converted into the new BigSMILES language. Furthermore, it is hoped that the proposed system will provide a more effective language for communication within the polymer community and increase cohesion between the researchers within the community.
Type
Journal article
Subject
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
LANGUAGE
MACHINE
SMILES
REPRESENTATION
PREDICTION
Permalink
https://hdl.handle.net/10161/19465
Published Version (Please cite this version)
10.1021/acscentsci.9b00476
Publication Info
Lin, Tzyy-Shyang; Coley, Connor W; Mochigase, Hidenobu; Beech, Haley K; Wang, Wencong; Wang, Zi; ... Olsen, Bradley D (2019). BigSMILES: A Structurally-Based Line Notation for Describing Macromolecules. ACS central science, 5(9). pp. 1523-1531. 10.1021/acscentsci.9b00476. Retrieved from https://hdl.handle.net/10161/19465.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Craig

Stephen L Craig

William T. Miller Distinguished Professor of Chemistry
Research interests in Prof. Craig's group bridge physical organic and materials chemistry. Many of these interests are guided by the vision that important challenges in materials science might be better tackled not from the traditional perspective of an engineer, but rather from the molecular perspective of an organic chemist. Current interests include the design and synthesis of self-healing polymers and the use of modern mechanochemistry in new stress-responsive polymers, catalysis, and the st
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