Skip to main content
Duke University Libraries
DukeSpace Scholarship by Duke Authors
  • Login
  • Ask
  • Menu
  • Login
  • Ask a Librarian
  • Search & Find
  • Using the Library
  • Research Support
  • Course Support
  • Libraries
  • About
View Item 
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER).

Thumbnail
View / Download
414.0 Kb
Date
2016-01
Authors
Buchheit, Thomas
Van de Ven, Thomas
Hsia, Hung-Lun John
McDuffie, Mary
MacLeod, David B
White, William
Chamessian, Alexander
Keefe, Francis J
Buckenmaier, Chester Trip
Shaw, Andrew D
Show More
(10 total)
Repository Usage Stats
42
views
12
downloads
Abstract
OBJECTIVE:To define clinical phenotypes of postamputation pain and identify markers of risk for the development of chronic pain. DESIGN:Cross-sectional study of military service members enrolled 3-18 months after traumatic amputation injury. SETTING:Military Medical Center. SUBJECTS:124 recent active duty military service members. METHODS:Study subjects completed multiple pain and psychometric questionnaires to assess the qualities of phantom and residual limb pain. Medical records were reviewed to determine the presence/absence of a regional catheter near the time of injury. Subtypes of residual limb pain (somatic, neuroma, and complex regional pain syndrome) were additionally analyzed and associated with clinical risk factors. RESULTS:A majority of enrolled patients (64.5%) reported clinically significant pain (pain score ≥ 3 averaged over previous week). 61% experienced residual limb pain and 58% experienced phantom pain. When analysis of pain subtypes was performed in those with residual limb pain, we found evidence of a sensitized neuroma in 48.7%, somatic pain in 40.8%, and complex regional pain syndrome in 19.7% of individuals. The presence of clinically significant neuropathic residual limb pain was associated with symptoms of PTSD and depression. Neuropathic pain of any severity was associated with symptoms of all four assessed clinical risk factors: depression, PTSD, catastrophizing, and the absence of regional analgesia catheter. CONCLUSIONS:Most military service members in this cohort suffered both phantom and residual limb pain following amputation. Neuroma was a common cause of neuropathic pain in this group. Associated risk factors for significant neuropathic pain included PTSD and depression. PTSD, depression, catastrophizing, and the absence of a regional analgesia catheter were associated with neuropathic pain of any severity.
Type
Journal article
Subject
Humans
Neuroma
Phantom Limb
Amputation, Traumatic
Pain Measurement
Analgesia
Amputation
Risk Factors
Cross-Sectional Studies
Depression
Adult
Veterans
Female
Male
Young Adult
Surveys and Questionnaires
Permalink
https://hdl.handle.net/10161/19638
Published Version (Please cite this version)
10.1111/pme.12848
Publication Info
Buchheit, Thomas; Van de Ven, Thomas; Hsia, Hung-Lun John; McDuffie, Mary; MacLeod, David B; White, William; ... Shaw, Andrew D (2016). Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER). Pain medicine (Malden, Mass.), 17(1). pp. 149-161. 10.1111/pme.12848. Retrieved from https://hdl.handle.net/10161/19638.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
  • Scholarly Articles
More Info
Show full item record

Scholars@Duke

Buchheit

Thomas Edward Buchheit

Associate Professor of Anesthesiology
Dr. Buchheit serves as Director of the Regenerative Pain Therapies Program in the Duke Center for Translational Pain Medicine (CTPM), and practices Pain Medicine at both Duke University and the Durham VAMC. His research focus is on the local and systemic inflammatory mechanisms that drive pain in arthritis and nerve injury. He has led and participated in several multicenter research projects that have studied patients at Duke, the Durham VAMC, and Walter Reed National Military Medical Ce
Hsia

Hung-Lun John Hsia

Assistant Professor of Anesthesiology
Keefe

Francis Joseph Keefe

Professor in Psychiatry and Behavioral Sciences
The primary aim of our research over the past year has been to evaluate the efficacy of cognitive-behavioral treatments for arthritis pain. We are conducting two treatment outcome studies supported by grants from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases. The first project, conducted with osteoarthritis patients, seeks to determine whether aerobic exercise training can enhance the effects of a cognitive behavior therapy (CBT) intervention for managing pain an
MacLeod

David Brett MacLeod

Associate Professor of Anesthesiology
Clinical Anesthesia My principal clinical interest is the use of peripheral nerve blocks in primarily orthopedic joint replacement procedures. I am a member of the Regional Division with responsibilities to spine, trauma & plastic surgery. I was the co-director of the Carolina Cadaver Course, which was run annually in conjunction with Wake Forest University School of Medicine. I have been involved in teaching the use of ultrasound for the placement of
Van de Ven

Thomas John Van de Ven

Assistant Professor of Anesthesiology
More Authors
Alphabetical list of authors with Scholars@Duke profiles.
Open Access

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

Rights for Collection: Scholarly Articles

Make Your Work Available Here

How to Deposit

Browse

All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

My Account

LoginRegister

Statistics

View Usage Statistics
Duke University Libraries

Contact Us

411 Chapel Drive
Durham, NC 27708
(919) 660-5870
Perkins Library Service Desk

Digital Repositories at Duke

  • Report a problem with the repositories
  • About digital repositories at Duke
  • Accessibility Policy
  • Deaccession and DMCA Takedown Policy

TwitterFacebookYouTubeFlickrInstagramBlogs

Sign Up for Our Newsletter
  • Re-use & Attribution / Privacy
  • Support the Libraries
Duke University