Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.
Abstract
RATIONALE:Hyperpolarized 129Xe ventilation MRI is typically acquired using multislice
fast gradient recalled echo (GRE), but interleaved 3D radial 129Xe gas transfer MRI
now provides dissolved-phase and ventilation images from a single breath. To investigate
whether these ventilation images provide equivalent quantitative metrics, we introduce
generalized linear binning analysis. METHODS:This study included 36 patients who had
undergone both multislice GRE ventilation and 3D radial gas exchange imaging. Images
were then quantified by linear binning to classify voxels into one of four clusters:
ventilation defect percentage (VDP), Low-, Medium- or High-ventilation percentage
(LVP, MVP, HVP). For 3D radial images, linear binning thresholds were generalized
using a Box-Cox rescaled reference histogram. We compared the cluster populations
from the two ventilation acquisitions both numerically and spatially. RESULTS:Interacquisition
Bland-Altman limits of agreement for the clusters between 3D radial vs GRE were (-7%
to 5%) for VDP, (-10% to 14%) for LVP, and (-8% to 8%) for HVP. While binning maps
were qualitatively similar between acquisitions, their spatial overlap was modest
for VDP (Dice = 0.5 ± 0.2), and relatively poor for LVP (0.3 ± 0.1) and HVP (0.2 ±
0.1). CONCLUSION:Both acquisitions yield reasonably concordant VDP and qualitatively
similar maps. However, poor regional agreement (Dice) suggests that the two acquisitions
cannot yet be used interchangeably. However, further improvements in 3D radial resolution
and reconciliation of bias field correction may well obviate the need for a dedicated
ventilation scan in many cases.
Type
Journal articlePermalink
https://hdl.handle.net/10161/19675Published Version (Please cite this version)
10.1016/j.acra.2019.10.016Publication Info
He, Mu; Wang, Ziyi; Rankine, Leith; Luo, Sheng; Nouls, John; Virgincar, Rohan; ...
Driehuys, Bastiaan (2019). Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived
from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI. Academic radiology. 10.1016/j.acra.2019.10.016. Retrieved from https://hdl.handle.net/10161/19675.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Bastiaan Driehuys
Professor of Radiology
My research program is focused on developing and applying hyperpolarized gases to
enable fundamentally new applications in MRI. Currently we use this technology to
non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning
nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus,
despite the low density of gases relative to water (the ordinary signal source in
MRI), they can be imaged at high-resolution in a single breath. This technology leads
Sheng Luo
Professor of Biostatistics & Bioinformatics
Joseph George Mammarappallil
Associate Professor of Radiology
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info