Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways.
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In metazoans, thousands of intracellular proteins are modified with O-linked β-N-acetylglucosamine (O-GlcNAc) in response to a wide range of stimuli and stresses. In particular, a complex and evolutionarily conserved interplay between O-GlcNAcylation and oxidative stress has emerged in recent years. Here, we review the current literature on the connections between O-GlcNAc and oxidative stress, with a particular emphasis on major signaling pathways, such as KEAP1/NRF2, FOXO, NFκB, p53 and cell metabolism. Taken together, this work sheds important light on the signaling functions of protein glycosylation and the mechanisms of stress responses alike and illuminates how the two are integrated in animal cell physiology.
Published Version (Please cite this version)10.1093/glycob/cwy027
Publication InfoBoyce, Michael; Chi, Jen-Tsan; & Chen, Po-Han (2018). Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways. Glycobiology, 28(8). pp. 556-564. 10.1093/glycob/cwy027. Retrieved from https://hdl.handle.net/10161/19688.
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Associate Professor of Biochemistry
The Boyce Lab studies mammalian cell signaling through protein glycosylation. For the latest news, project information and publications from our group, please visit our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab.
Associate Professor in Molecular Genetics and Microbiology
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