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Caspases: an ancient cellular sword of Damocles.

dc.contributor.author Boyce, M
dc.contributor.author Degterev, A
dc.contributor.author Yuan, J
dc.date.accessioned 2020-01-01T17:17:32Z
dc.date.available 2020-01-01T17:17:32Z
dc.date.issued 2004-01
dc.identifier 4401339
dc.identifier.issn 1350-9047
dc.identifier.issn 1476-5403
dc.identifier.uri https://hdl.handle.net/10161/19708
dc.description.abstract Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Cell death and differentiation
dc.relation.isversionof 10.1038/sj.cdd.4401339
dc.subject Animals
dc.subject Humans
dc.subject Caspases
dc.subject Caenorhabditis elegans Proteins
dc.subject Evolution, Molecular
dc.subject Apoptosis
dc.title Caspases: an ancient cellular sword of Damocles.
dc.type Journal article
duke.contributor.id Boyce, M|0599420
dc.date.updated 2020-01-01T17:17:32Z
pubs.begin-page 29
pubs.end-page 37
pubs.issue 1
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Biochemistry
pubs.organisational-group Basic Science Departments
pubs.publication-status Published
pubs.volume 11
duke.contributor.orcid Boyce, M|0000-0002-2729-4876


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