The relationship of mental and behavioral disorders to all-cause mortality in a 27-year follow-up of 4 epidemiologic catchment area samples.
Abstract
Subjects from the Epidemiologic Catchment Area Program, interviewed during 1979-1983,
were linked to data in the National Death Index through 2007 to estimate the association
of mental and behavioral disorders with death. There were more than 25 years of follow-up
for 15,440 individuals, with 6,924 deaths amounting to 307,881 person-years of observation.
Data were analyzed by using age as the time scale and parametric approaches to quantify
the years of life lost due to disorders. Alcohol, drug use, and antisocial personality
disorders were associated with increased risk of death, but there was no strong association
with mood and anxiety disorders. Results of high- and low-quality matches with the
National Death Index were similar. The 3 behavioral disorders were associated with
5-15 years of life lost, estimated along the life course via the generalized gamma
model. Regression tree analyses showed that risk of death was associated with alcohol
use disorders in nonblacks and with drug disorders in blacks. Phobia interacted with
alcohol use disorders in nonblack women, and obsessive-compulsive disorder interacted
with drug use disorders in black men. Both of these anxiety disorders were associated
with lower risk of death early in life and higher risk of death later in life.
Type
Journal articleSubject
HumansSubstance-Related Disorders
Prevalence
Proportional Hazards Models
Follow-Up Studies
Mental Disorders
Anxiety Disorders
Mood Disorders
Antisocial Personality Disorder
Age Factors
Sex Factors
Adolescent
Adult
Aged
Middle Aged
Continental Population Groups
United States
Female
Male
Young Adult
Kaplan-Meier Estimate
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https://hdl.handle.net/10161/19979Published Version (Please cite this version)
10.1093/aje/kwt219Publication Info
Eaton, William W; Roth, Kimberly B; Bruce, Martha; Cottler, Linda; Wu, Litzy; Nestadt,
Gerald; ... Muñoz, Alvaro (2013). The relationship of mental and behavioral disorders to all-cause mortality in a 27-year
follow-up of 4 epidemiologic catchment area samples. American journal of epidemiology, 178(9). pp. 1366-1377. 10.1093/aje/kwt219. Retrieved from https://hdl.handle.net/10161/19979.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Li-Tzy Wu
Professor in Psychiatry and Behavioral Sciences
Education/Training: Pre- and post-doctoral training in mental health service research,
psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns
Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute
on the Design and Conduct of Randomized Clinical Trials.Director: Duke Community Based
Substance Use Disorder Research Program.Research interests: COVID-19, Opioid misuse,
Opioid overdose, Opioid use disorder

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