Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent individuals: results from the Clinical Trials Network.
Abstract
The sample included 343 opioid-dependent adults enrolled in two national multisite
studies of the National Drug Abuse Treatment Clinical Trials Network (CTN001-002).
Opioid-dependent individuals were recruited from 12 sites across the United States
from January 2001 to July 2002. We examined associations between depressive symptoms,
co-occurring substance use (i.e., the use of substances other than opioids), and HIV-related
sexual and injection risk behaviors. Data were collected using the Addiction Severity
Index and the HIV Risk Behavior Scale, and analyzed using linear regression. Depressive
symptoms were associated with an increased level of injection risk behaviors but were
not associated with risky sexual behaviors. The co-occurring use of amphetamines also
increased the likelihood of risky sexual behaviors. The study limitations and clinical
implications are noted. The study was funded by the U.S. National Institute on Drug
Abuse.
Type
Journal articleSubject
HumansHIV Infections
HIV Seropositivity
Amphetamine-Related Disorders
Opioid-Related Disorders
Cross-Sectional Studies
Depression
Behavior, Addictive
Risk-Taking
Sexual Behavior
Adolescent
Adult
Middle Aged
Female
Male
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https://hdl.handle.net/10161/19994Published Version (Please cite this version)
10.3109/10826084.2011.611960Publication Info
Pilowsky, Daniel J; Wu, Li-Tzy; Burchett, Bruce; Blazer, Dan G; & Ling, Walter (2011). Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent
individuals: results from the Clinical Trials Network. Substance use & misuse, 46(14). pp. 1716-1725. 10.3109/10826084.2011.611960. Retrieved from https://hdl.handle.net/10161/19994.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Daniel German Blazer
J. P. Gibbons Distinguished Professor Emeritus of Psychiatry
I am currently semi-retired. Most of my recent work has been focused on roles with
the National Academy of Medicine (former Institute of Medicine). I have chaired three
committees during the past four years, one on the mental health and substance use workforce,
one on cognitive aging, and one on hearing loss in adults. I currently also chair
the Board on the Health of Select Populations for the National Academies. In the past
I have been PI on a number of research
Bruce Myatt Burchett
Assistant Professor in Psychiatry and Behavioral Sciences
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Li-Tzy Wu
Professor in Psychiatry and Behavioral Sciences
Education/Training: Pre- and post-doctoral training in mental health service research,
psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns
Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute
on the Design and Conduct of Randomized Clinical Trials.Director: Duke Community Based
Substance Use Disorder Research Program.Research interests: COVID-19, Opioid misuse,
Opioid overdose, Opioid use disorder, Opio
Alphabetical list of authors with Scholars@Duke profiles.

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