| dc.description.abstract |
<p>Cationic gold carbene complexes have attracted significant attention, being postulated
as intermediates in a range of gold-catalyzed transformations. Regardless of the remarkable
progress in the gold (I) catalysis, our fundamental understanding on the key intermediate
species and the subsequent reactivity, and mechanistic insight is deficient. This
is mainly due to the lack of proper model system with sufficient reactivity, as the
majority of known gold carbene complexes are heteroatom stabilized or sterically hindered,
and because of a dearth of direct intermediate observations in catalytic systems.
Lewis acid mediated leaving group abstraction from a neutral gold precursor provides
a convenient method for the generation of rare examples of reactive gold carbene species
in high yield and purity, addressing the issue with isolation of such transient species
as well as allowing in situ spectroscopic analysis. Subsequent trapping experiment
with nucleophiles provides kinetic information about relevant catalytic transformations,
and the -ionization strategy is further extended toward generation of transient
-cationic propyl gold species for studying gold to alkene carbene transfer reaction.</p>
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