Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.
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To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis.Cartilage-bone samples from the medial femoral condyle and tibial plateau of 12 month-old guinea pig knees were subjected to osmotic loading. Site-matched swelling strains and fixed charge density values were used in a triphasic theoretical model for cartilage swelling to determine the modulus of the cartilage solid matrix. The degree of cartilage degeneration was assessed in adjacent tissue sections using a semi-quantitative histological grading scheme.Decreased values for both moduli and surface zone fixed charge density were associated with increasing grades of cartilage degeneration. Decreases in moduli reflect damage to the collagen matrix, which give rise to greater swelling strains.Histological evidence of cartilage degeneration was associated with impaired cartilage mechanics in the aging Hartley guinea pig.
Published Version (Please cite this version)10.1016/j.joca.2004.01.007
Publication InfoFlahiff, Charlene M; Kraus, Virginia B; Huebner, Janet L; & Setton, Lori A (2004). Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method. Osteoarthritis and cartilage, 12(5). pp. 383-388. 10.1016/j.joca.2004.01.007. Retrieved from https://hdl.handle.net/10161/20238.
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Clinical Research Coordinator, Tier 2
Virginia Byers Kraus
Mary Bernheim Distinguished Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench. The work in this laboratory focuses on osteoarthritis and deals w
Lori A. Setton
Adjunct Professor of Biomedical Engineering
Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused on engineering and evaluating materials for tissue regeneration and drug delivery. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues. Re
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