Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.
Abstract
To determine the material properties of articular cartilage in the Hartley guinea
pig model of spontaneous osteoarthritis.Cartilage-bone samples from the medial femoral
condyle and tibial plateau of 12 month-old guinea pig knees were subjected to osmotic
loading. Site-matched swelling strains and fixed charge density values were used in
a triphasic theoretical model for cartilage swelling to determine the modulus of the
cartilage solid matrix. The degree of cartilage degeneration was assessed in adjacent
tissue sections using a semi-quantitative histological grading scheme.Decreased values
for both moduli and surface zone fixed charge density were associated with increasing
grades of cartilage degeneration. Decreases in moduli reflect damage to the collagen
matrix, which give rise to greater swelling strains.Histological evidence of cartilage
degeneration was associated with impaired cartilage mechanics in the aging Hartley
guinea pig.
Type
Journal articleSubject
Cartilage, ArticularPatella
Tibia
Knee Joint
Animals
Guinea Pigs
Cartilage Diseases
Osteoarthritis
Osmotic Pressure
Elasticity
Stress, Mechanical
Tensile Strength
Male
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https://hdl.handle.net/10161/20238Published Version (Please cite this version)
10.1016/j.joca.2004.01.007Publication Info
(2004). Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic
loading method. Osteoarthritis and cartilage, 12(5). pp. 383-388. 10.1016/j.joca.2004.01.007. Retrieved from https://hdl.handle.net/10161/20238.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Charlene Flahiff
Clinical Research Coordinator, Tier 2
Virginia Byers Kraus
Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis.
Osteoarthritis is the most common form of joint disease in man and its incidence increases
with age. It is a problem of increasing concern to the medical community due to the
increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist,
I endeavor to study this disease from bedside to bench. The work in this laboratory
focuses on osteoarthritis and deals w
Lori A. Setton
Adjunct Professor of Biomedical Engineering
Research in Setton's laboratory is focused on the role of mechanical factors in the
degeneration and repair of soft tissues of the musculoskeletal system, including the
intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused
on engineering and evaluating materials for tissue regeneration and drug delivery.
Studies combining engineering and biology are also used to determine the role of mechanical
factors to promote and control healing of cartilaginous tissues. Re
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