A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.
Abstract
Although electrical neurostimulation has been proposed as an alternative treatment
for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation,
vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients.
Here we demonstrate a closed loop brain-machine interface that delivers electrical
stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures.
Rats were implanted with cortical recording microelectrodes and spinal cord stimulating
electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures
were detected in real time from cortical local field potentials, after which DCS was
applied. This method decreased seizure episode frequency by 44% and seizure duration
by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical
theta waves, and propose that this closed-loop interface has the potential to become
an effective and semi-invasive treatment for refractory epilepsy and other neurological
disorders.
Type
Journal articleSubject
AnimalsRats, Long-Evans
Epilepsy
Seizures
Pentylenetetrazole
Female
Male
Spinal Cord Stimulation
Brain-Computer Interfaces
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https://hdl.handle.net/10161/20278Published Version (Please cite this version)
10.1038/srep32814Publication Info
Pais-Vieira, Miguel; Yadav, Amol P; Moreira, Derek; Guggenmos, David; Santos, Amílcar;
Lebedev, Mikhail; & Nicolelis, Miguel AL (2016). A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical
Stimulation. Scientific reports, 6(1). pp. 32814. 10.1038/srep32814. Retrieved from https://hdl.handle.net/10161/20278.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Miguel Angelo L. Nicolelis
Professor Emeritus of Neurobiology
Miguel Nicolelis, M.D., Ph.D., is the Duke School of Medicine Distinguished Professor
of Neuroscience, Duke University Professor of Neurobiology, Biomedical Engineering
and Psychology and Neuroscience, and founder of Duke's Center for Neuroengineering.
He is the founder and Scientific Director of the Edmond and Lily Safra International
Institute for Neuroscience of Natal. Dr. Nicolelis is also founder of the Walk Again
Project, an international consortium of scientists and engineers, de
Amol Yadav
Postdoctoral Associate
Dr. Yadav is a neuroscientist and biomedical engineer, currently a postdoctoral associate
in the Department of Neurosurgery where he collaborates with neurosurgeons on translational
neuroscience research.
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