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A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.

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Date
2016-09-08
Authors
Pais-Vieira, Miguel
Yadav, Amol P
Moreira, Derek
Guggenmos, David
Santos, Amílcar
Lebedev, Mikhail
Nicolelis, Miguel AL
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Abstract
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.
Type
Journal article
Subject
Animals
Rats, Long-Evans
Epilepsy
Seizures
Pentylenetetrazole
Female
Male
Spinal Cord Stimulation
Brain-Computer Interfaces
Permalink
https://hdl.handle.net/10161/20278
Published Version (Please cite this version)
10.1038/srep32814
Publication Info
Pais-Vieira, Miguel; Yadav, Amol P; Moreira, Derek; Guggenmos, David; Santos, Amílcar; Lebedev, Mikhail; & Nicolelis, Miguel AL (2016). A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific reports, 6(1). pp. 32814. 10.1038/srep32814. Retrieved from https://hdl.handle.net/10161/20278.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Nicolelis

Miguel Angelo L. Nicolelis

Professor Emeritus of Neurobiology
Miguel Nicolelis, M.D., Ph.D., is the Duke School of Medicine Distinguished Professor of Neuroscience, Duke University Professor of Neurobiology, Biomedical Engineering and Psychology and Neuroscience, and founder of Duke's Center for Neuroengineering. He is the founder and Scientific Director of the Edmond and Lily Safra International Institute for Neuroscience of Natal.  Dr. Nicolelis is also founder of the Walk Again Project, an international consortium of scientists and engineers, de
Yadav

Amol Yadav

Postdoctoral Associate
Dr. Yadav is a neuroscientist and biomedical engineer, currently a postdoctoral associate in the Department of Neurosurgery where he collaborates with neurosurgeons on translational neuroscience research.
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