Show simple item record

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease.

dc.contributor.author Yadav, Amol P
dc.contributor.author Nicolelis, Miguel AL
dc.date.accessioned 2020-03-31T04:47:17Z
dc.date.available 2020-03-31T04:47:17Z
dc.date.issued 2017-06
dc.identifier.issn 0885-3185
dc.identifier.issn 1531-8257
dc.identifier.uri https://hdl.handle.net/10161/20281
dc.description.abstract Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could become an effective treatment for motor symptoms associated with Parkinson's disease (PD). Since our initial report in rodents and a more recent study in primates, several clinical studies have now described beneficial effects of dorsal column stimulation in parkinsonian patients. In primates, we have shown that dorsal column stimulation activates multiple structures along the somatosensory pathway and desynchronizes the pathological cortico-striatal oscillations responsible for the manifestation of PD symptoms. Based on recent evidence, we argue that neurological disorders such as PD can be broadly classified as diseases emerging from abnormal neuronal timing, leading to pathological brain states, and that the spinal cord could be used as a "channel" to transmit therapeutic electrical signals to disrupt these abnormalities. © 2017 International Parkinson and Movement Disorder Society.
dc.language eng
dc.publisher Wiley
dc.relation.ispartof Movement disorders : official journal of the Movement Disorder Society
dc.relation.isversionof 10.1002/mds.27033
dc.subject Animals
dc.subject Humans
dc.subject Parkinson Disease
dc.subject Spinal Cord Stimulation
dc.subject Spinal Cord Dorsal Horn
dc.title Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease.
dc.type Journal article
duke.contributor.id Yadav, Amol P|0480720
duke.contributor.id Nicolelis, Miguel AL|0099178
dc.date.updated 2020-03-31T04:47:15Z
pubs.begin-page 820
pubs.end-page 832
pubs.issue 6
pubs.organisational-group School of Medicine
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Neurobiology
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Neurosurgery
pubs.organisational-group Neurology, Behavioral Neurology
pubs.organisational-group Duke
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Neurology
pubs.organisational-group Staff
pubs.publication-status Published
pubs.volume 32
duke.contributor.orcid Yadav, Amol P|0000-0002-4913-8006


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record