Trial design for assessing analytical and clinical performance of high-sensitivity cardiac troponin I assays in the United States: The HIGH-US study.
ACS, acute coronary syndrome
AMI, acute myocardial infarction
CLSI, Clinical and Laboratory Standards Institute
High-sensitivity cardiac troponin
Li-Hep, lithium heparin
LoB, Limit of Blank
LoD, Limit of Detection
LoQ, Limit of Quantitation
MDP, Medical Decision Pools
NPV, negative predictive value
PPV, positive predictive value
Sex-specific 99th percentile cutoffs
URL, upper reference limit
cTn, cardiac troponin
cTnI, cardiac troponin I
hs-cTn, high-sensitivity cardiac troponin
hs-cTnI, High-Sensitivity Troponin I
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info
Showing items related by title, author, creator, and subject.
The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States. Fitzgerald, Robert L; Hollander, Judd E; Peacock, W Frank; Limkakeng, Alexander T; Breitenbeck, Nancy; Rivers, E Joy; Ziegler, André; ... (9 authors) (Clinica chimica acta; international journal of clinical chemistry, 2020-05)BACKGROUND:Determining diagnostic thresholds for cardiac troponin assays is key to interpreting their clinical performance. We describe the calculation of 99th percentile upper reference limits (URLs) for the Elecsys® Troponin ...
A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. Reinoso, Tyler R; Landim-Vieira, Maicon; Shi, Yun; Johnston, Jamie R; Chase, P Bryant; Parvatiyar, Michelle S; Landstrom, Andrew P; ... (9 authors) (Journal of muscle research and cell motility, 2020-11-11)Familial cardiomyopathy is an inherited disease that affects the structure and function of heart muscle and has an extreme range of phenotypes. Among the millions of affected individuals, patients with hypertrophic (HCM), ...
Ely, Sora; Chandra, Abhinav; Mani, Giselle; Drake, Weiying; Freeman, Debbie; Limkakeng, Alexander T (Journal of Emergency Medicine, 2013-02)BACKGROUND: Determining which patients presenting to the Emergency Department (ED) require further work-up for acute coronary syndrome (ACS) can be difficult. The utility of routine observation for cardiac testing in low-risk ...