How Diffusion Impacts Cortical Protein Distribution in Yeasts.
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Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved.
Published Version (Please cite this version)10.3390/cells9051113
Publication InfoMoran, Kyle D; & Lew, Daniel J (2020). How Diffusion Impacts Cortical Protein Distribution in Yeasts. Cells, 9(5). pp. 1113-1113. 10.3390/cells9051113. Retrieved from https://hdl.handle.net/10161/20714.
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Daniel Julio Lew
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology
Our research interests focus on the control of cell polarity. Cell polarity is a nearly universal feature of eukaryotic cells. A polarized cell usually has a single, clear axis of asymmetry: a “front” and a “back”. In the past several years it has become apparent that the highly conserved Rho-family GTPase Cdc42, first discovered in yeast, is a component of a master pathway, employed time and again to promote polarity in different contexts.
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