How Diffusion Impacts Cortical Protein Distribution in Yeasts.
Abstract
Proteins associated with the yeast plasma membrane often accumulate asymmetrically
within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse
processes, including polarized growth, stress sensing, and aging. Here, we review
our evolving understanding of how cells achieve asymmetric distributions of membrane
proteins despite the anticipated dissipative effects of diffusion, and highlight recent
findings suggesting that differential diffusion is exploited to create, rather than
dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma
membranes that remain unsolved.
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https://hdl.handle.net/10161/20714Published Version (Please cite this version)
10.3390/cells9051113Publication Info
Moran, Kyle D; & Lew, Daniel J (2020). How Diffusion Impacts Cortical Protein Distribution in Yeasts. Cells, 9(5). pp. 1113-1113. 10.3390/cells9051113. Retrieved from https://hdl.handle.net/10161/20714.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Daniel Julio Lew
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology
Our research interests focus on the control of cell polarity. Cell polarity is a
nearly universal feature of eukaryotic cells. A polarized cell usually has a single,
clear axis of asymmetry: a “front” and a “back”. In the past
several years it has become apparent that the highly conserved Rho-family GTPase Cdc42,
first discovered in yeast, is a component of a master pathway, employed time and again
to promote polarity in different contexts.
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.

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