Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.
Abstract
Online repetitive transcranial magnetic stimulation (rTMS), applied while subjects
are performing a task, is widely used to disrupt brain regions underlying cognition.
However, online rTMS has also induced "paradoxical enhancement". Given the rapid proliferation
of this approach, it is crucial to develop a better understanding of how online stimulation
influences cognition, and the optimal parameters to achieve desired effects. To accomplish
this goal, a quantitative meta-analysis was performed with random-effects models fitted
to reaction time (RT) and accuracy data. The final dataset included 126 studies published
between 1998 and 2016, with 244 total effects for reaction times, and 202 for accuracy.
Meta-analytically, rTMS at 10 Hz and 20 Hz disrupted accuracy for attention, executive,
language, memory, motor, and perception domains, while no effects were found with
1 Hz or 5 Hz. Stimulation applied at and 10 and 20 Hz slowed down RTs in attention
and perception tasks. No performance enhancement was found. Meta-regression analysis
showed that fMRI-guided targeting and short inter-trial intervals are associated with
increased disruptive effects with rTMS.
Type
Journal articlePermalink
https://hdl.handle.net/10161/20727Published Version (Please cite this version)
10.1016/j.neubiorev.2019.08.018Publication Info
(2019). Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive
processing: A meta-analysis and recommendations for future studies. Neuroscience and biobehavioral reviews, 107. pp. 47-58. 10.1016/j.neubiorev.2019.08.018. Retrieved from https://hdl.handle.net/10161/20727.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Lawrence Gregory Appelbaum
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Greg Appelbaum is an Adjunct Associate Professor in the Department of Psychiatry and
Behavioral Sciences in the Duke University School of Medicine. Dr. Appelbaum's research
interests primarily concern the brain mechanisms underlying visual cognition, how
these capabilities differ among individuals, and how they can be improved through
behavioral, neurofeedback, and neuromodulation interventions. Within the field of
cognitive neuroscience, his research has addressed visual pe
Roberto Cabeza
Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young
and older adults using fMRI. We have three main lines of research: First, we distinguish
the neural correlates of various episodic memory processes. For example, we have compared
encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false
memory, and emotional vs. nonemotional memory. We are particularly interested in the
contribution of prefrontal cortex (PFC) and medial temporal lobe (M
Simon Wilton Davis
Assistant Professor in Neurology
My research centers around the use of structural and functional imaging measures to
study the shifts in network architecture in the aging brain. I am specifically interested
in changes in how changes in structural and functional connectivity associated with
aging impact the semantic retrieval of word or fact knowledge. Currently this involves
asking why older adults have particular difficulty in certain kinds of semantic retrieval,
despite the fact that vocabularies and knowledge stores typic
Zhi-de Deng
Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
Sarah Hollingsworth Lisanby
Professor Emeritus of Psychiatry and Behavioral Sciences
Sarah Hollingsworth “Holly” Lisanby, MD, is an experienced translational
researcher and innovator of neuromodulation technologies to study and treat psychiatric
disorders. Dr. Lisanby is Director of the Division of Translational Research at NIMH,
which funds research on the discovery of preventions, treatments, and cures for mental
illness across the lifespan. She is Founder and Director of the Noninvasive Neuromodulation
Unit in the NIMH Intramural Research Progra
Bruce M. Luber
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
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