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Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula.

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Date
2019-05
Authors
Addicott, Merideth A
Luber, Bruce
Nguyen, Duy
Palmer, Hannah
Lisanby, Sarah H
Appelbaum, Lawrence Gregory
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Abstract
The insular cortex supports the conscious awareness of physical and emotional sensations, and the ability to modulate the insula could have important clinical applications in psychiatry. Repetitive transcranial magnetic stimulation (rTMS) uses transient magnetic fields to induce electrical currents in the superficial cortex. Given its deep location in the brain, the insula may not be directly stimulated by rTMS; however, rTMS may modulate the insula via its functional connections with superficial cortical regions. Furthermore, low- versus high-frequency rTMS is thought to have opposing effects on cortical excitability, and the present study investigated these effects on brain activity and functional connectivity with the insula. Separate groups of healthy participants (n = 14 per group) received low (1 Hz)- or high (10 Hz)-frequency rTMS in five daily sessions to the right postcentral gyrus, a superficial region known to be functionally connected to the insula. Resting-state functional connectivity (RSFC) was measured pre- and post-rTMS. Both 1 and 10 Hz rTMS increased RSFC between the right postcentral gyrus and the left insula. These results suggest that low- and high-frequency rTMS has similar long-term effects on brain activity and RSFC. However, given the lack of difference, we cannot exclude the possibility that these effects are simply due to a nonspecific effect. Given this limitation, these unexpected results underscore the need for acoustic- and stimulation-matched sham control conditions in rTMS research.
Type
Journal article
Subject
Brain
Cerebral Cortex
Prefrontal Cortex
Somatosensory Cortex
Nerve Net
Neural Pathways
Humans
Magnetic Resonance Imaging
Electroencephalography
Adult
Aged
Middle Aged
Female
Transcranial Magnetic Stimulation
Connectome
Healthy Volunteers
Multimodal Imaging
Permalink
https://hdl.handle.net/10161/20728
Published Version (Please cite this version)
10.1089/brain.2018.0652
Publication Info
Addicott, Merideth A; Luber, Bruce; Nguyen, Duy; Palmer, Hannah; Lisanby, Sarah H; & Appelbaum, Lawrence Gregory (2019). Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula. Brain connectivity, 9(4). pp. 322-328. 10.1089/brain.2018.0652. Retrieved from https://hdl.handle.net/10161/20728.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Addicott

Merideth A Addicott

Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
Appelbaum

Lawrence Gregory Appelbaum

Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Greg Appelbaum is an Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences in the Duke University School of Medicine.  Dr. Appelbaum's research interests primarily concern the brain mechanisms underlying visual cognition, how these capabilities differ among individuals, and how they can be improved through behavioral, neurofeedback, and neuromodulation interventions. Within the field of cognitive neuroscience, his research has addressed visual pe
Lisanby

Sarah Hollingsworth Lisanby

Professor Emeritus of Psychiatry and Behavioral Sciences
Sarah Hollingsworth “Holly” Lisanby, MD, is an experienced translational researcher and innovator of neuromodulation technologies to study and treat psychiatric disorders. Dr. Lisanby is Director of the Division of Translational Research at NIMH, which funds research on the discovery of preventions, treatments, and cures for mental illness across the lifespan.  She is Founder and Director of the Noninvasive Neuromodulation Unit in the NIMH Intramural Research Progra

Bruce M. Luber

Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Alphabetical list of authors with Scholars@Duke profiles.
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