Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula.
Abstract
The insular cortex supports the conscious awareness of physical and emotional sensations,
and the ability to modulate the insula could have important clinical applications
in psychiatry. Repetitive transcranial magnetic stimulation (rTMS) uses transient
magnetic fields to induce electrical currents in the superficial cortex. Given its
deep location in the brain, the insula may not be directly stimulated by rTMS; however,
rTMS may modulate the insula via its functional connections with superficial cortical
regions. Furthermore, low- versus high-frequency rTMS is thought to have opposing
effects on cortical excitability, and the present study investigated these effects
on brain activity and functional connectivity with the insula. Separate groups of
healthy participants (n = 14 per group) received low (1 Hz)- or high (10 Hz)-frequency
rTMS in five daily sessions to the right postcentral gyrus, a superficial region known
to be functionally connected to the insula. Resting-state functional connectivity
(RSFC) was measured pre- and post-rTMS. Both 1 and 10 Hz rTMS increased RSFC between
the right postcentral gyrus and the left insula. These results suggest that low- and
high-frequency rTMS has similar long-term effects on brain activity and RSFC. However,
given the lack of difference, we cannot exclude the possibility that these effects
are simply due to a nonspecific effect. Given this limitation, these unexpected results
underscore the need for acoustic- and stimulation-matched sham control conditions
in rTMS research.
Type
Journal articleSubject
BrainCerebral Cortex
Prefrontal Cortex
Somatosensory Cortex
Nerve Net
Neural Pathways
Humans
Magnetic Resonance Imaging
Electroencephalography
Adult
Aged
Middle Aged
Female
Transcranial Magnetic Stimulation
Connectome
Healthy Volunteers
Multimodal Imaging
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https://hdl.handle.net/10161/20728Published Version (Please cite this version)
10.1089/brain.2018.0652Publication Info
Addicott, Merideth A; Luber, Bruce; Nguyen, Duy; Palmer, Hannah; Lisanby, Sarah H;
& Appelbaum, Lawrence Gregory (2019). Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State
Functional Connectivity Between the Postcentral Gyrus and the Insula. Brain connectivity, 9(4). pp. 322-328. 10.1089/brain.2018.0652. Retrieved from https://hdl.handle.net/10161/20728.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Merideth A Addicott
Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
Lawrence Gregory Appelbaum
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Greg Appelbaum is an Adjunct Associate Professor in the Department of Psychiatry and
Behavioral Sciences in the Duke University School of Medicine. Dr. Appelbaum's research
interests primarily concern the brain mechanisms underlying visual cognition, how
these capabilities differ among individuals, and how they can be improved through
behavioral, neurofeedback, and neuromodulation interventions. Within the field of
cognitive neuroscience, his research has addressed visual pe
Sarah Hollingsworth Lisanby
Professor Emeritus of Psychiatry and Behavioral Sciences
Sarah Hollingsworth “Holly” Lisanby, MD, is an experienced translational
researcher and innovator of neuromodulation technologies to study and treat psychiatric
disorders. Dr. Lisanby is Director of the Division of Translational Research at NIMH,
which funds research on the discovery of preventions, treatments, and cures for mental
illness across the lifespan. She is Founder and Director of the Noninvasive Neuromodulation
Unit in the NIMH Intramural Research Progra
Bruce M. Luber
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
This author no longer has a Scholars@Duke profile, so the information shown here reflects
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