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Distress tolerance to auditory feedback and functional connectivity with the auditory cortex.
Abstract
Distress tolerance is the capacity to withstand negative affective states in pursuit
of a goal. Low distress tolerance may bias an individual to avoid or escape experiences
that induce affective distress, but the neural mechanisms underlying the bottom-up
generation of distress and its relationship to behavioral avoidance are poorly understood.
During a neuroimaging scan, healthy participants completed a mental arithmetic task
with easy and distress phases, which differed in cognitive demands and positive versus
negative auditory feedback. Then, participants were given the opportunity to continue
playing the distress phase for a financial bonus and were allowed to quit at any time.
The persistence duration was the measure of distress tolerance. The easy and distress
phases activated auditory cortices and fronto-parietal regions. A task-based functional
connectivity analysis using the left secondary auditory cortex (i.e., planum temporale)
as the seed region revealed stronger connectivity to fronto-parietal regions and anterior
insula during the distress phase. The distress-related connectivity between the seed
region and the left anterior insula was negatively correlated with distress tolerance.
The results provide initial evidence of the role of the anterior insula as a mediating
link between the bottom-up generation of affective distress and top-down behavioral
avoidance of distress.
Type
Journal articleSubject
Auditory CortexNerve Net
Humans
Magnetic Resonance Imaging
Acoustic Stimulation
Stress, Psychological
Emotions
Psychomotor Performance
Adult
Female
Male
Young Adult
Feedback, Sensory
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https://hdl.handle.net/10161/20731Published Version (Please cite this version)
10.1016/j.pscychresns.2018.10.003Publication Info
Addicott, Merideth A; Daughters, Stacey B; Strauman, Timothy J; & Appelbaum, L Gregory (2018). Distress tolerance to auditory feedback and functional connectivity with the auditory
cortex. Psychiatry research. Neuroimaging, 282. pp. 1-10. 10.1016/j.pscychresns.2018.10.003. Retrieved from https://hdl.handle.net/10161/20731.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Merideth A Addicott
Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
Lawrence Gregory Appelbaum
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Greg Appelbaum is an Adjunct Associate Professor in the Department of Psychiatry and
Behavioral Sciences in the Duke University School of Medicine. Dr. Appelbaum's research
interests primarily concern the brain mechanisms underlying visual cognition, how
these capabilities differ among individuals, and how they can be improved through
behavioral, neurofeedback, and neuromodulation interventions. Within the field of
cognitive neuroscience, his research has addressed visual pe
Timothy J. Strauman
Professor of Psychology and Neuroscience
FOR POTENTIAL STUDENTS (fall 2024 class):
Dr. Timothy Strauman and Dr. Ann Brewster will be seeking to admit a student for Fall
2024 who will be an important member of their collaborative projects. Dr. Brewster
is an intervention scientist and a faculty member in Duke’s Social Science Research
Institute. The collaborative projects focus on creating, testing, and implementing
school-based therapeutic and preventive interventions for adolescents at risk for
negative academic and me
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