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<p>Purpose: Total body irradiation (TBI) is to deplete patient’s bone marrow and suppress
the immune system by delivering uniform dose to patient’s whole body with a relatively
low dose rate. The widely used total body irradiation (TBI) protocol in many institutions
is to extend the source to surface distance (SSD) to over 400 cm in a large treatment
room. The TBI techniques currently used at Duke University Medical Center is anteroposterior
(AP)/posteroanterior (PA) technique and bilateral technique. Though bilateral technique
TBI is executed with simpler treatment planning and setups in a more comfortable position,
it could not provide adequate shielding to lungs and kidneys using blocks like AP/PA
TBI technique. However, the whole process of block fabricating and verification is
labor-consuming and time-costing. This project aims to develop a better AP/PA TBI
treatment method in recumbent position, which provides better sparing for lungs and
kidneys in any treatment room.</p><p>Methods: In this study, we considered different
treatment techniques (three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated
radiation therapy (IMRT)), different treatment position (on the floor or on the couch),
and different setups (gantry rotation and platform movement). TBI treatment plans
were simulated in Eclipse treatment planning system by using both water equivalent
phantom and patient CT image. Prescription for the treatment plans was 200 cGy per
fraction with 4 fractions. The dose homogeneity should within ±10% of the prescription
dose. Dose constraints for kidney and lung are 25% of the prescription dose. In 3DCRT
TBI, we applied multi-leaf collimators (MLCs) for OARs shielding and used boost field
to provide adequate dose to lungs and kidneys. For IMRT TBI, an iterative optimization
algorithm was generated for increasing dose uniformity. By using IMRT, dynamic multi-leaf
collimators (DMLCs) provided shielding for kidneys and lungs, which were considered
in fluence map optimization. Volume dose and dose profiles were used to analyze the
dose uniformity. Measurements with solid water phantom in treatment room were performed
to verify the simulation results. IMRT QA with portal imager was performed for phantom.</p><p>Results:
3DCRT could not ensure the dose homogeneity and dose deliver accuracy at the same
time. To ensure the dose homogeneity in 3DCRT TBI, patient/platform position should
be changed between field or applying customized wedge to compensate the inverse square
law. For IMRT, the optimization algorithm has excellent performance for both phantom
and patients. The dose homogeneity in the mid-plane of both phantom and patients were
less than ±5% of the prescription dose after a few iterations. Lungs and kidneys could
receive around 25% prescription dose. The simulation and measurement results agree
with each other. No additional physical compensators or partial transmission blocks
were needed. Portal dose and predict dose perfectly agreed with each other. CR film
worked well in positioning. Surface dose enhancement under blocked field was observed.
</p><p>Conclusion: IMRT technique performed much better than 3DCRT in TBI treatment.
In this study, we develop an AP/PA recumbent position IMRT TBI technique that could
be used in any linac room. This technique can ensure high dose homogeneity, provide
better sparing to lungs and kidneys, and reduce the complexity of TBI treatment planning
without the need of labor-intensive compensators and partial transmission blocks.</p>
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