Quantitative topographic curvature maps of the posterior eye utilizing optical coherence tomography.
Abstract
PURPOSE:Deformations of the retina such as staphylomas in myopia or scleral flattening
in high intracranial pressure can be challenging to quantify with en face imaging.
We describe an OCT based method for the generation of quantitative posterior eye topography
maps in normal and pathologic eyes. METHODS:Utilizing "whole eye" OCT we corrected
for subjects' optical distortions to generate spatially accurate posterior eye OCT
volumes and created local curvature (KM, mm) topography maps for each consented subject.
We imaged nine subjects, three normal, two with myopic degeneration (MD), and four
with papilledema including one that was imaged longitudinally. RESULTS:Normal subjects
mean temporal KM was 0.0923 mm, nasal KM was 0.0927 mm, and KM local variability was
0.0162 mm. In MD subjects KM local variability was higher at 0.0836 mm. In papilledema
subjects nasal KM was flatter compared to temporal KM (0.0709 mm vs. 0.0885 mm). Mean
intrasession KM repeatability for all subjects was 0.0036 mm. CONCLUSION:We have developed
an OCT based method for quantitative posterior eye topography that offers the ability
to analyze local curvature with micron scale resolution and offers the potential to
help clinicians and researchers characterize subtle, local retinal deformations earlier
in patients and follow their development over time.
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https://hdl.handle.net/10161/21199Published Version (Please cite this version)
10.1097/iae.0000000000002897Publication Info
(2020). Quantitative topographic curvature maps of the posterior eye utilizing optical coherence
tomography. Retina (Philadelphia, Pa.), Publish Ahead of Print. 10.1097/iae.0000000000002897. Retrieved from https://hdl.handle.net/10161/21199.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Mays Antoine Dairi
Associate Professor of Ophthalmology
1. Pediatric and adult optic neuropathies 2. Optic nerve imaging (mainly optical coherence
tomography) 3. Idiopathic intracranial hypertension 4. Optic neuritis
Sidney Maloch Gospe III
Assistant Professor of Ophthalmology
Dr. Gospe joined Duke Ophthalmology on August 1, 2017 following his neuro-ophthalmology
fellowship training at Duke. His research interests center on developing novel genetic
mouse models of severe mitochondrial dysfunction in retinal ganglion cells (RGCs)
and other retinal neurons in order to recapitulate the RGC degeneration seen in human
optic neuropathies and the poorly understood pigmentary retinopathy that may accompany
these diseases.
Mitochondria are the powerhouse o
Joseph A. Izatt
Michael J. Fitzpatrick Distinguished Professor of Engineering
My research centers on the development and application of cutting-edge optical technologies
for non-invasive, high-resolution imaging and sensing in living biological tissues.
Our laboratory is recognized for foundational contributions to optical coherence-based
approaches for in vivo sub-surface microscopic tissue imaging, particularly optical
coherence tomography (OCT) which has become a standard of care in ophthalmology and
other clinical specialties. The technologies we employ includ
Charlene Lillian James
Assistant Professor of Ophthalmology
Dr. Charlene James is an optometrist who works in the comprehensive clinic at Duke
Eye Center. In her practice she enjoys providing comprehensive eye care which includes
screening for conditions such as cataracts, glaucoma, diabetic retinopathy, and macular
degeneration. She also provides post-operative care for those undergoing cataract
surgery and contact lens evaluations.
She is passionate about promoting eye health and educating her patients on the importance
of taking care of the
Anthony Nanlin Kuo
Associate Professor of Ophthalmology
Anthony Kuo, MD is an Associate Professor of Ophthalmology and Assistant Professor
of Biomedical Engineering at Duke University. He is a clinician-scientist with an
active clinical practice in cornea and refractive surgery and an active laboratory
program developing and translating high resolution optical coherence tomography (OCT)
technologies for ophthalmic use. With collaborators at Duke, he is also involved in
the development and translation of intra-surgical OCT technologies.
Ryan McNabb
Medical Instructor in the Department of Ophthalmology
Dr. McNabb is an engineer by training with a research focus on combining optical coherence
tomography (OCT) and robots for use in the ophthalmology clinic. He recently joined
the Department of Ophthalmology faculty after post-doctoral training and serving as
a lead Research Scientist under Dr. Anthony Kuo at the Duke Eye Center.
He enjoys working closely with clinicians to combine technology and medicine. He is
the principal investigator on an NIH R21 grant for “Assistive Roboti
Robin Raul Vann
Associate Professor of Ophthalmology
I am interested in a medical treatment alternative for conjunctival intraepithelial
neoplasia. Along with Dr. Carol Karp, I have developed a successful medical treatment
regimen for these patients. I would like to continue using our medical treatment regimen
and further establish the optimum dosing and frequency for eradicating this disease.
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