Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research NetworkShow More
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<h4>Objective</h4>To compare neurodevelopmental outcomes in linear growth-restricted (LGR) infants born <29 weeks with and without weight gain out of proportion to linear growth.<h4>Study design</h4>We compared 2-year neurodevelopmental outcomes between infants with and without LGR and between LGR infants with and without weight gain out of proportion to linear growth. The outcomes were Bayley-III cognitive, motor, and language scores, cerebral palsy, Gross Motor Function Classification System (GMFCS) level ≥ 2, and neurodevelopmental impairment.<h4>Result</h4>In total, 1227 infants were analyzed. LGR infants were smaller and less mature at birth, had higher BMI, and had lower Bayley-III language scores (82.3 vs. 85.0, p < 0.05). Among infants with LGR, infants with high BMI had lower language scores compared with those with low-to-normal BMI (80.8 vs. 83.3, p < 0.05), and were more likely to have GMFCS level ≥2 and neurodevelopmental impairment.<h4>Conclusion</h4>Among infants with LGR, weight gain out of proportion to linear growth was associated with poorer neurodevelopmental outcomes.
SubjectEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Language Development Disorders
National Institute of Child Health and Human Development (U.S.)
Infant, Extremely Premature
Published Version (Please cite this version)10.1038/s41372-018-0259-8
Publication InfoMeyers, JM; Tan, S; Bell, EF; Duncan, AF; Guillet, R; Stoll, BJ; ... Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2019). Neurodevelopmental outcomes among extremely premature infants with linear growth restriction. Journal of perinatology : official journal of the California Perinatal Association, 39(2). pp. 193-202. 10.1038/s41372-018-0259-8. Retrieved from https://hdl.handle.net/10161/22267.
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