Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
Abstract
<h4>Objective</h4>To compare neurodevelopmental outcomes in linear growth-restricted
(LGR) infants born <29 weeks with and without weight gain out of proportion to linear
growth.<h4>Study design</h4>We compared 2-year neurodevelopmental outcomes between
infants with and without LGR and between LGR infants with and without weight gain
out of proportion to linear growth. The outcomes were Bayley-III cognitive, motor,
and language scores, cerebral palsy, Gross Motor Function Classification System (GMFCS)
level ≥ 2, and neurodevelopmental impairment.<h4>Result</h4>In total, 1227 infants
were analyzed. LGR infants were smaller and less mature at birth, had higher BMI,
and had lower Bayley-III language scores (82.3 vs. 85.0, p < 0.05). Among infants
with LGR, infants with high BMI had lower language scores compared with those with
low-to-normal BMI (80.8 vs. 83.3, p < 0.05), and were more likely to have GMFCS level
≥2 and neurodevelopmental impairment.<h4>Conclusion</h4>Among infants with LGR, weight
gain out of proportion to linear growth was associated with poorer neurodevelopmental
outcomes.
Type
Journal articleSubject
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal
Research NetworkHumans
Cerebral Palsy
Language Development Disorders
Weight Gain
Retrospective Studies
Cognition Disorders
Developmental Disabilities
Neuropsychological Tests
Databases, Factual
Infant
Infant, Newborn
United States
Female
Male
National Institute of Child Health and Human Development (U.S.)
Infant, Extremely Premature
Motor Disorders
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https://hdl.handle.net/10161/22267Published Version (Please cite this version)
10.1038/s41372-018-0259-8Publication Info
Meyers, JM; Tan, S; Bell, EF; Duncan, AF; Guillet, R; Stoll, BJ; ... Eunice Kennedy
Shriver National Institute of Child Health and Human Development Neonatal Research
Network (2019). Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.
Journal of perinatology : official journal of the California Perinatal Association, 39(2). pp. 193-202. 10.1038/s41372-018-0259-8. Retrieved from https://hdl.handle.net/10161/22267.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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