DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway
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Published Version (Please cite this version)10.1038/s41388-021-01676-x
Publication InfoLin, Chao-Chieh; Yang, Wen-Hsuan; Lin, Yi-Tzu; Tang, Xiaohu; Chen, Po-Han; Ding, Chien-Kuang Cornelia; ... Chi, Jen-Tsan (n.d.). DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. Oncogene. 10.1038/s41388-021-01676-x. Retrieved from https://hdl.handle.net/10161/22378.
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Associate Professor in Molecular Genetics and Microbiology
We are using functional genomic approaches to investigate the nutrient signaling and stress adaptations of cancer cells when exposed to various nutrient deprivations and microenvironmental stress conditions. Recently, we focus on two areas. First, we are elucidating the genetic determinants and disease relevance of ferroptosis, a newly recognized form of cell death. Second, we have identified the mammalian stringent response pathway which is highly similar to bacterial stringent response, but