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Coronavirus disease 2019 vaccines in pregnancy.

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Date
2020-12-10
Authors
Craig, Amanda M
Hughes, Brenna L
Swamy, Geeta K
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Abstract
As of December 1, 2020, nearly 64 million people have been infected with the severe acute respiratory syndrome coronavirus 2 worldwide with nearly 1.5 million global deaths. The impact of this virus has continued to overwhelm hospital infrastructure and demanded remodeling of healthcare systems. With rising concerns for a third, and possibly the largest, wave of individuals infected with the virus, national leaders are continuing to seek avenues by which we can further limit disease transmission and prevent infection with the use of vaccination. To our knowledge, no clinical trial evaluating vaccines to prevent coronavirus disease 2019 has included pregnant women. In December 2020, it was anticipated that the Food and Drug Administration will approve at least 1 or 2 mRNA-based coronavirus disease 2019 vaccine under the Emergency Use Authorization based on phase 3 clinical trial efficacy data. Both Pfizer and Moderna have manufactured mRNA-based vaccines with 95% and 94.1% efficacy against the severe acute respiratory syndrome coronavirus 2. AstraZeneca has manufactured a vaccine using a viral vector demonstrating early efficacy as well, and this next-generation platform has previously been utilized with the Ebola vaccine and safely administered during pregnancy with an acceptable safety profile. Approval of these vaccines will have a tremendous impact on the ongoing pandemic, yet there remains a lack of data for use of coronavirus disease 2019 vaccine in pregnant women. In this article, we seek to discuss the available data regarding treatment and prevention of coronavirus disease 2019 in pregnancy and address the growing questions regarding how best to approach vaccine access and administration in the pregnant population.
Type
Journal article
Subject
coronavirus disease 2019
maternal mortality
pandemic
pregnancy
remdesivir
vaccination
vaccine
Permalink
https://hdl.handle.net/10161/22419
Published Version (Please cite this version)
10.1016/j.ajogmf.2020.100295
Publication Info
Craig, Amanda M; Hughes, Brenna L; & Swamy, Geeta K (2020). Coronavirus disease 2019 vaccines in pregnancy. American journal of obstetrics & gynecology MFM, 3(2). pp. 100295. 10.1016/j.ajogmf.2020.100295. Retrieved from https://hdl.handle.net/10161/22419.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Hughes

Brenna L Hughes

Associate Professor of Obstetrics and Gynecology
Swamy

Geeta Krishna Swamy

Professor of Obstetrics and Gynecology
Dr. Geeta Swamy, MD, is Professor of Obstetrics and Gynecology in the Division of Maternal-Fetal Medicine, having served as the director of the Duke Perinatal Research Center and Vice Chair for Research and Faculty Development in the Department of ObGyn. She has achieved international acclaim as a clinician researcher and expert in the field of maternal immunization and perinatal infection. As a consultant to the World Health Organization, Dr. Swamy contributes her knowledge to advance inte
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