A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays.
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Diffuse reflectance spectroscopy (DRS) is a well-established method to quantitatively distinguish between benign and cancerous tissue for tumor margin assessment. Current multipixel DRS margin assessment tools are bulky fiber-based probes that have limited scalability. Reported herein is a new approach to multipixel DRS probe design, which utilizes direct detection of the DRS signal by using optimized custom photodetectors in direct contact with the tissue. This first fiberless DRS imaging system for tumor margin assessment consists of a 4 × 4 array of annular silicon photodetectors and a constrained free-space light delivery tube optimized to deliver light across a 256 mm(2) imaging area. This system has 4.5 mm spatial resolution. The signal-to-noise ratio measured for normal and malignant breast tissue-mimicking phantoms was 35 dB to 45 dB for λ = 470 nm to 600 nm.
Published Version (Please cite this version)10.1364/boe.3.003211
Publication InfoDhar, Sulochana; Lo, Justin Y; Palmer, Gregory M; Brooke, Martin A; Nichols, Brandon S; Yu, Bing; ... Jokerst, Nan M (2012). A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays. Biomedical optics express, 3(12). pp. 3211-3222. 10.1364/boe.3.003211. Retrieved from https://hdl.handle.net/10161/22464.
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Martin A. Brooke
Associate Professor of Electrical and Computer Engineering
Martin A. Brooke received the B.E. (Elect.) Degree (1st. Class Hons.) from Auckland University in New Zealand in 1981. He received the M.S. and Ph. D. in Electrical Engineering from The University of Southern California in 1984, and 1988, respectively. He is currently an Associate Professor of Electrical Engineering at Duke University. Professor Brooke was an Analog Devices Career development award recipient from 1988-1993, won a National Science Foundation Research Initiation Award in 1990, the
Nan Marie Jokerst
J. A. Jones Distinguished Professor of Electrical and Computer Engineering
Dr. Nan Marie Jokerst is the J. A. Jones Distinguished Professor of Electrical and Computer Engineering at Duke University, and the Executive Director of the Duke Shared Materials Instrumentation Facility, a Duke shared cleanroom and characterization facility. She received her BS in Physics from Creighton University in 1982, and her MS and PhD in Electrical Engineering from the University of Southern California in 1984 and 1989, respectively. She is a Fellow of the IEEE, and has served as an el
Gregory M. Palmer
Associate Professor of Radiation Oncology
Greg Palmer obtained his B.S. in Biomedical Engineering from Marquette University in 2000, after which he obtained his Ph.D. in BME from the University of Wisconsin, Madison. He is currently an Associate Professor in the Department of Radiation Oncology, Cancer Biology Division at Duke University Medical Center. His primary research focus has been identifying and exploiting the changes in absorption, scattering, and fluorescence properties of tissue associated with cancer progression and therape
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