Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.
Abstract
The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown.
Patients with leukemia may display altered thromboinflammatory responses. We report
a 53-year-old man presenting with acute leukemia and COVID-19 who developed thrombotic
complications and acute respiratory distress syndrome. Multiple analyses, including
rotational thromboelastometry and flow cytometry on blood and bronchoalveolar lavage,
are reported to characterize coagulation and immune profiles. The patient developed
chemotherapy-induced neutropenia that may have protected his lungs from granulocyte-driven
hyperinflammatory acute lung injury. However, neutropenia also alters viral clearing,
potentially enabling ongoing viral propagation. This case depicts a precarious equilibrium
between leukemia and COVID-19.
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https://hdl.handle.net/10161/22473Published Version (Please cite this version)
10.1213/xaa.0000000000001432Publication Info
(2021). Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute
Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia:
A Case Report. A&A practice, 15(4). pp. e01432. 10.1213/xaa.0000000000001432. Retrieved from https://hdl.handle.net/10161/22473.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Bryan David Kraft
Adjunct Assistant Professor in the Department of Medicine
Dr. Kraft has a wide variety of clinical and research interests, including sepsis,
pneumonia, and acute respiratory distress syndrome (ARDS), and has special expertise
in rare lung diseases such as pulmonary fibrosis and pulmonary alveolar proteinosis
(PAP). PAP can be congenital, hereditary, autoimmune, or due to occupational exposures
(e.g. dusts, fibers, silica). Dr. Kraft performs whole lung lavage (WLL) at Duke in
a state-of-the art hyperbaric chamber within the Duke C
Jerrold Henry Levy
Professor of Anesthesiology
Jerrold Levy is Professor of Anesthesiology, Critical Care, and Surgery (Cardiothoracic)
at Duke University Medical Center in Durham, NC. He obtained his medical degree from
the University of Miami, where he was an intern in internal medicine, and undertook
his residency in the Department of Anesthesiology of the Massachusetts General Hospital
and Harvard Medical School in Boston, where he was also Chief Resident, and completed
fellowships in both Respiratory ICU and Cardiac Anesthesiology. 
Smita K Nair
Professor in Surgery
I have 22 years of experience in the field of cancer vaccines and immunotherapy and
I am an accomplished T cell immunologist. Laboratory website:https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory
Current projects in the Nair Laboratory:1] Dendritic cell vaccines using tumor-antigen
encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)<br
Loretta Georgina Que
Professor of Medicine
My research interests focus on studying the role of nitric oxide and related enzymes
in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative
stress. Proposed studies are performed in cell culture and applied to animal models
of disease, then examined in human disease where relevant. It is our hope that by
better understanding the role of NO and reactive nitrogen species in mediating inflammation,
and regulating cell signaling, that we will not only help to unr
Bruce Alan Sullenger
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery
The main focus of my translational research laboratory is to develop RNA based therapeutic
agents for the potential treatment of a range of diseases. To this end, we have and
will continue to take advantage of the fact that RNA is not just a passive carrier
of genetic instructions inside of cells during the conversion of information from
DNA to RNA to protein. Rather, RNA is an extremely versatile biological macromolecule.
Certian RNAs can bind to specific protiens with high affinities,
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