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Pathway-specific asymmetries between ON and OFF visual signals

dc.contributor.author Ravi, Sneha
dc.contributor.author Ahn, Daniel
dc.contributor.author Greschner, Martin
dc.contributor.author Chichilnisky, EJ
dc.contributor.author Field, Greg
dc.date.accessioned 2021-04-01T14:34:28Z
dc.date.available 2021-04-01T14:34:28Z
dc.identifier.uri https://hdl.handle.net/10161/22494
dc.description.abstract <jats:title>Abstract</jats:title><jats:p>Visual processing is largely organized into ON and OFF pathways that signal stimulus increments and decrements, respectively. These pathways exhibit natural pairings based on morphological and physiological similarities, such as ON and OFF alpha ganglion cells in the mammalian retina. Several studies have noted asymmetries in the properties of ON and OFF pathways. For example, the spatial receptive fields (RFs) of OFF alpha cells are systematically smaller than ON alpha cells. Analysis of natural scenes suggests these asymmetries are optimal for visual encoding. To test the generality of ON-OFF asymmetries, we measured the spatiotemporal RF properties of multiple RGC types in rat retina. Through a quantitative and serial classification, we identified three functional pairs of ON and OFF RGCs. We analyzed the structure of their RFs and compared spatial integration, temporal integration, and gain across ON and OFF pairs. Similar to previous results from cat and primate, RGC types with larger spatial RFs exhibited briefer temporal integration and higher gain. However, each pair of ON and OFF RGC types exhibited distinct asymmetric relationships between receptive field properties, some of which were opposite to previous reports. These results reveal the functional organization of six RGC types in the rodent retina and indicate that ON-OFF asymmetries are pathway specific.</jats:p><jats:sec><jats:title>Significance Statement</jats:title><jats:p>Circuits that process sensory input frequently process increments separately from decrements, so called ‘ON’ and ‘OFF’ responses. Theoretical studies indicate this separation, and associated asymmetries in ON and OFF pathways, may be beneficial for encoding natural stimuli. However, the generality of ON and OFF pathway asymmetries has not been tested. Here we compare the functional properties of three distinct pairs of ON and OFF pathways in the rodent retina and show their asymmetries are pathway specific. These results provide a new view on the partitioning of vision across diverse ON and OFF signaling pathways</jats:p></jats:sec>
dc.publisher Cold Spring Harbor Laboratory
dc.relation.isversionof 10.1101/384891
dc.title Pathway-specific asymmetries between ON and OFF visual signals
dc.type Journal article
duke.contributor.id Field, Greg|0663656
dc.date.updated 2021-04-01T14:34:28Z
pubs.organisational-group School of Medicine
pubs.organisational-group Neurobiology
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke
pubs.organisational-group Basic Science Departments
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
duke.contributor.orcid Field, Greg|0000-0001-5942-2679


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