Skip to main content
Duke University Libraries
DukeSpace Scholarship by Duke Authors
  • Login
  • Ask
  • Menu
  • Login
  • Ask a Librarian
  • Search & Find
  • Using the Library
  • Research Support
  • Course Support
  • Libraries
  • About
View Item 
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection.

Thumbnail
View / Download
599.0 Kb
Date
2017-06
Authors
Cordero, Daniella M
Towe, Sheri L
Chen, Nan-Kuei
Robertson, Kevin R
Madden, David J
Huettel, Scott A
Meade, Christina S
Repository Usage Stats
29
views
7
downloads
Abstract
This study investigated the association of HIV infection and cocaine dependence with cerebral white matter integrity using diffusion tensor imaging (DTI). One hundred thirty-five participants stratified by HIV and cocaine status (26 HIV+/COC+, 37 HIV+/COC-, 37 HIV-/COC+, and 35 HIV-/COC-) completed a comprehensive substance abuse assessment, neuropsychological testing, and MRI with DTI. Among HIV+ participants, all were receiving HIV care and 46% had an AIDS diagnosis. All COC+ participants were current users and met criteria for cocaine use disorder. We used tract-based spatial statistics (TBSS) to assess the relation of HIV and cocaine to fractional anisotropy (FA) and mean diffusivity (MD). In whole-brain analyses, HIV+ participants had significantly reduced FA and increased MD compared to HIV- participants. The relation of HIV and FA was widespread throughout the brain, whereas the HIV-related MD effects were restricted to the corpus callosum and thalamus. There were no significant cocaine or HIV-by-cocaine effects. These DTI metrics correlated significantly with duration of HIV disease, nadir CD4+ cell count, and AIDS diagnosis, as well as some measures of neuropsychological functioning. These results suggest that HIV is related to white matter integrity throughout the brain, and that HIV-related effects are more pronounced with increasing duration of infection and greater immune compromise. We found no evidence for independent effects of cocaine dependence on white matter integrity, and cocaine dependence did not appear to exacerbate the effects of HIV.
Type
Journal article
Subject
Thalamus
Cerebral Cortex
Corpus Callosum
CD4-Positive T-Lymphocytes
Humans
HIV Infections
Cocaine-Related Disorders
CD4 Lymphocyte Count
Case-Control Studies
Neuropsychological Tests
Anisotropy
Adult
Middle Aged
Female
Male
Diffusion Tensor Imaging
White Matter
Permalink
https://hdl.handle.net/10161/22532
Published Version (Please cite this version)
10.1007/s13365-017-0512-5
Publication Info
Cordero, Daniella M; Towe, Sheri L; Chen, Nan-Kuei; Robertson, Kevin R; Madden, David J; Huettel, Scott A; & Meade, Christina S (2017). Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection. Journal of neurovirology, 23(3). pp. 441-450. 10.1007/s13365-017-0512-5. Retrieved from https://hdl.handle.net/10161/22532.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
  • Scholarly Articles
More Info
Show full item record

Scholars@Duke

Chen

Nan-kuei Chen

Adjunct Associate Professor in the Department of Radiology
Dr. Chen is a magnetic resonance imaging (MRI) physicist with research interest in fast image acquisition methodology, pulse sequence design, MRI artifact correction, and application of MRI to studies of neurological diseases. He has been developing novel high-resolution imaging protocols and analysis procedures for mapping structural and functional connectivity of brains. More generally, Dr. Chen's research involves the application of MRI in translational contexts. He has been serving as the pr
Huettel

Scott Huettel

Professor in the Department of Psychology and Neuroscience
Research in my laboratory investigates the brain mechanisms underlying economic and social decision making; collectively, this research falls into the field of “decision neuroscience” or "neuroeconomics". My laboratory uses fMRI to probe brain function, behavioral assays to characterize individual differences, and other physiological methods (e.g., eye tracking, pharmacological manipulation, genetics) to link brain and behavior. Concurrent with research on basic processes, my labo
Madden

David Joseph Madden

Professor in Psychiatry and Behavioral Sciences
My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from mo
Meade

Christina S. Meade

Associate Professor in Psychiatry and Behavioral Sciences
Dr. Meade’s domestic research program focuses on predictors of HIV risk behavior in adults with substance use and psychiatric disorders, and the relationship between neuropsychiatric conditions and continued risk behavior in HIV-positive adults. She is particularly interested in how drug addiction and HIV infection impact executive functions, such as decision making, that lead individuals to engage in risky behaviors. Many of her current projects incorporate MRI to isolate the effe
Towe

Sheri L Towe

Assistant Professor in Psychiatry and Behavioral Sciences
More Authors
Alphabetical list of authors with Scholars@Duke profiles.
Open Access

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

Rights for Collection: Scholarly Articles


Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info

Make Your Work Available Here

How to Deposit

Browse

All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

My Account

LoginRegister

Statistics

View Usage Statistics
Duke University Libraries

Contact Us

411 Chapel Drive
Durham, NC 27708
(919) 660-5870
Perkins Library Service Desk

Digital Repositories at Duke

  • Report a problem with the repositories
  • About digital repositories at Duke
  • Accessibility Policy
  • Deaccession and DMCA Takedown Policy

TwitterFacebookYouTubeFlickrInstagramBlogs

Sign Up for Our Newsletter
  • Re-use & Attribution / Privacy
  • Harmful Language Statement
  • Support the Libraries
Duke University