Gatekeepers of the fetus: Characterization of placental macrophages.
Abstract
In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide
elegant technological and conceptual advances that further our understanding of the
immune cells enriched at the maternal-fetal interface. Using new isolation strategies
to better separate maternal- and fetal-derived cells, the authors identify previously
undefined maternal-derived immune cells associated with the fetal-derived placenta
and provide an in-depth analysis of the markers and characteristics of placental Hofbauer
cells.
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Journal articlePermalink
https://hdl.handle.net/10161/22571Published Version (Please cite this version)
10.1084/jem.20202071Publication Info
(2021). Gatekeepers of the fetus: Characterization of placental macrophages. The Journal of experimental medicine, 218(1). 10.1084/jem.20202071. Retrieved from https://hdl.handle.net/10161/22571.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Carolyn Coyne
George Barth Geller Distinguished Professor of Immunology
We study the pathways by which microorganisms cross cellular barriers and the mechanisms
by which these barriers restrict microbial infections. Our studies primarily focus
on the epithelium that lines the gastrointestinal tract and on placental trophoblasts,
the cells that comprise a key cellular barrier of the human placenta. Our work is
highly multidisciplinary and encompasses aspects of cell biology, immunology, and
microbiology. Our long-term goals are to identify pathogen- and host-spe
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