Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
Abstract
Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate
hosts from multiple phyla and can successfully infect most cells within these organisms.
The infection outcome in each of these species is determined by the complex interaction
between parasite and host genotype. As techniques to quantify global changes in cell
function become more readily available and precise, new data are coming to light about
how (i) different host cell types respond to parasitic infection and (ii) different
parasite species impact the host. Here we focus on recent studies comparing the response
to intracellular parasitism by different cell types and insights into understanding
host-parasite interactions from comparative studies on T. gondii and its close extant
relatives.
Type
Journal articleSubject
Cell LineAnimals
Mammals
Humans
Apicomplexa
Neospora
Toxoplasma
Coccidiosis
Toxoplasmosis
Protein-Serine-Threonine Kinases
Chemokines
Virulence
Immunity
Gene Expression
Tumor Suppressor Protein p53
Host-Parasite Interactions
Interferon-gamma
Biological Evolution
Host Specificity
Transcriptome
THP-1 Cells
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https://hdl.handle.net/10161/22576Published Version (Please cite this version)
10.1016/j.ijpara.2020.05.001Publication Info
Wong, Zhee S; Borrelli, Sarah L Sokol; Coyne, Carolyn C; & Boyle, Jon P (2020). Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
International journal for parasitology, 50(5). pp. 423-431. 10.1016/j.ijpara.2020.05.001. Retrieved from https://hdl.handle.net/10161/22576.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Carolyn Coyne
George Barth Geller Distinguished Professor of Immunology
We study the pathways by which microorganisms cross cellular barriers and the mechanisms
by which these barriers restrict microbial infections. Our studies primarily focus
on the epithelium that lines the gastrointestinal tract and on placental trophoblasts,
the cells that comprise a key cellular barrier of the human placenta. Our work is
highly multidisciplinary and encompasses aspects of cell biology, immunology, and
microbiology. Our long-term goals are to identify pathogen- and host-spe

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