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Type III Interferons in Antiviral Defenses at Barrier Surfaces.

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Date
2018-10
Authors
Wells, Alexandra I
Coyne, Carolyn B
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Abstract
Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of interferons (IFNs), which induce a strong antiviral state following receptor binding. However, whereas type I IFNs control infection systemically, type III IFNs (IFN-λs) control infection locally at barrier surfaces and are often preferentially induced by these cells. In this review we focus on the role of IFN-λ at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections.
Type
Journal article
Subject
Gastrointestinal Tract
Respiratory System
Blood-Brain Barrier
Placenta
Animals
Humans
Virus Diseases
Interferons
Pregnancy
Female
Skin Physiological Phenomena
Permalink
https://hdl.handle.net/10161/22583
Published Version (Please cite this version)
10.1016/j.it.2018.08.008
Publication Info
Wells, Alexandra I; & Coyne, Carolyn B (2018). Type III Interferons in Antiviral Defenses at Barrier Surfaces. Trends in immunology, 39(10). pp. 848-858. 10.1016/j.it.2018.08.008. Retrieved from https://hdl.handle.net/10161/22583.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Carolyn Coyne

Professor of Molecular Genetics and Microbiology
We study the pathways by which microorganisms cross cellular barriers and the mechanisms by which these barriers restrict microbial infections. Our studies primarily focus on the epithelium that lines the gastrointestinal tract and on placental trophoblasts, the cells that comprise a key cellular barrier of the human placenta. Our work is highly multidisciplinary and encompasses aspects of cell biology, immunology, and microbiology. Our long-term goals are to identify pathogen- and host-spe
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