STING'ing Zika virus in neurons.
Abstract
Studies in Drosophila reveal that the insect homologue of the stimulator of interferon
genes (STING) exerts antiviral activity against Zika virus infection in the fly brain
through the induction of autophagy, providing key insights into the possible evolutionary
function of STING in antiviral defence.
Type
Journal articleSubject
BrainAnimals
Humans
Drosophila melanogaster
Disease Models, Animal
Drosophila Proteins
Membrane Proteins
Autophagy
Zika Virus
Zika Virus Infection
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https://hdl.handle.net/10161/22584Published Version (Please cite this version)
10.1038/s41564-018-0232-5Publication Info
(2018). STING'ing Zika virus in neurons. Nature microbiology, 3(9). pp. 975-976. 10.1038/s41564-018-0232-5. Retrieved from https://hdl.handle.net/10161/22584.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Carolyn Coyne
George Barth Geller Distinguished Professor of Immunology
We study the pathways by which microorganisms cross cellular barriers and the mechanisms
by which these barriers restrict microbial infections. Our studies primarily focus
on the epithelium that lines the gastrointestinal tract and on placental trophoblasts,
the cells that comprise a key cellular barrier of the human placenta. Our work is
highly multidisciplinary and encompasses aspects of cell biology, immunology, and
microbiology. Our long-term goals are to identify pathogen- and host-spe
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