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Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.

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Date
2018-03-10
Authors
Lanik, Wyatt E
Mara, Madison A
Mihi, Belgacem
Coyne, Carolyn B
Good, Misty
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Abstract
Studies on the intestinal epithelial response to viral infection have previously been limited by the absence of in vitro human intestinal models that recapitulate the multicellular complexity of the gastrointestinal tract. Recent technological advances have led to the development of "mini-intestine" models, which mimic the diverse cellular nature and physiological activity of the small intestine. Utilizing adult or embryonic intestinal tissue, enteroid and organoid systems, respectively, represent an opportunity to effectively model cellular differentiation, proliferation, and interactions that are specific to the specialized environment of the intestine. Enteroid and organoid systems represent a significant advantage over traditional in vitro methods because they model the structure and function of the small intestine while also maintaining the genetic identity of the host. These more physiologic models also allow for novel approaches to investigate the interaction of enteric viruses with the gastrointestinal tract, making them ideal to study the complexities of host-pathogen interactions in this unique cellular environment. This review aims to provide a summary on the use of human enteroid and organoid systems as models to study virus pathogenesis.
Type
Journal article
Subject
Gastrointestinal Tract
Intestines
Organoids
Stem Cells
Humans
Enterovirus Infections
Models, Biological
Host-Pathogen Interactions
Permalink
https://hdl.handle.net/10161/22585
Published Version (Please cite this version)
10.3390/v10030124
Publication Info
Lanik, Wyatt E; Mara, Madison A; Mihi, Belgacem; Coyne, Carolyn B; & Good, Misty (2018). Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses, 10(3). pp. 124-124. 10.3390/v10030124. Retrieved from https://hdl.handle.net/10161/22585.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Coyne

Carolyn Coyne

George Barth Geller Distinguished Professor of Immunology
We study the pathways by which microorganisms cross cellular barriers and the mechanisms by which these barriers restrict microbial infections. Our studies primarily focus on the epithelium that lines the gastrointestinal tract and on placental trophoblasts, the cells that comprise a key cellular barrier of the human placenta. Our work is highly multidisciplinary and encompasses aspects of cell biology, immunology, and microbiology. Our long-term goals are to identify pathogen- and host-spe
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