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Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.

dc.contributor.author Lanik, Wyatt E
dc.contributor.author Mara, Madison A
dc.contributor.author Mihi, Belgacem
dc.contributor.author Coyne, Carolyn B
dc.contributor.author Good, Misty
dc.date.accessioned 2021-04-16T19:58:09Z
dc.date.available 2021-04-16T19:58:09Z
dc.date.issued 2018-03-10
dc.identifier v10030124
dc.identifier.issn 1999-4915
dc.identifier.issn 1999-4915
dc.identifier.uri https://hdl.handle.net/10161/22585
dc.description.abstract Studies on the intestinal epithelial response to viral infection have previously been limited by the absence of in vitro human intestinal models that recapitulate the multicellular complexity of the gastrointestinal tract. Recent technological advances have led to the development of "mini-intestine" models, which mimic the diverse cellular nature and physiological activity of the small intestine. Utilizing adult or embryonic intestinal tissue, enteroid and organoid systems, respectively, represent an opportunity to effectively model cellular differentiation, proliferation, and interactions that are specific to the specialized environment of the intestine. Enteroid and organoid systems represent a significant advantage over traditional in vitro methods because they model the structure and function of the small intestine while also maintaining the genetic identity of the host. These more physiologic models also allow for novel approaches to investigate the interaction of enteric viruses with the gastrointestinal tract, making them ideal to study the complexities of host-pathogen interactions in this unique cellular environment. This review aims to provide a summary on the use of human enteroid and organoid systems as models to study virus pathogenesis.
dc.language eng
dc.publisher MDPI AG
dc.relation.ispartof Viruses
dc.relation.isversionof 10.3390/v10030124
dc.subject Gastrointestinal Tract
dc.subject Intestines
dc.subject Organoids
dc.subject Stem Cells
dc.subject Humans
dc.subject Enterovirus Infections
dc.subject Models, Biological
dc.subject Host-Pathogen Interactions
dc.title Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.
dc.type Journal article
duke.contributor.id Coyne, Carolyn B|1086848
dc.date.updated 2021-04-16T19:58:08Z
pubs.begin-page 124
pubs.end-page 124
pubs.issue 3
pubs.organisational-group School of Medicine
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Duke
pubs.organisational-group Basic Science Departments
pubs.publication-status Published
pubs.volume 10
duke.contributor.orcid Coyne, Carolyn B|0000-0002-1884-6309


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