Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.
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Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked, microporous scaffolds composed of microgel building blocks and were previously shown to accelerate wound healing. To promote more extensive tissue ingrowth before scaffold degradation, we aimed to slow MAP degradation by switching the chirality of the crosslinking peptides from L- to D-amino acids. Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro, D-peptide crosslinked MAP hydrogel (D-MAP) hastened material degradation in vivo and imparted significant tissue regeneration to healed cutaneous wounds, including increased tensile strength and hair neogenesis. MAP scaffolds recruit IL-33 type 2 myeloid cells, which is amplified in the presence of D-peptides. Remarkably, D-MAP elicited significant antigen-specific immunity against the D-chiral peptides, and an intact adaptive immune system was required for the hydrogel-induced skin regeneration. These findings demonstrate that the generation of an adaptive immune response from a biomaterial is sufficient to induce cutaneous regenerative healing despite faster scaffold degradation.
Published Version (Please cite this version)10.1038/s41563-020-00844-w
Publication InfoGriffin, Donald R; Archang, Maani M; Kuan, Chen-Hsiang; Weaver, Westbrook M; Weinstein, Jason S; Feng, An Chieh; ... Scumpia, Philip O (2021). Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. Nature materials, 20(4). pp. 560-569. 10.1038/s41563-020-00844-w. Retrieved from https://hdl.handle.net/10161/22757.
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Professor of Biomedical Engineering
Professor Tatiana Segura received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. Her graduate work in designing and understanding non-viral gene delivery from hydrogel scaffolds was supervised by Prof. Lonnie Shea. She pursued post-doctoral training at the Swiss Federal Institute of Technology, Lausanne under the guidance of Prof. Jeffrey Hubbell, where her focus was self-assem