Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience.
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Understanding the factors that influence functional ability over the life course is integral to identifying clinical and public health policies to facilitate successful aging. The World Health Organization has advocated a conceptual framework to clarify the policy discussion. We have sought to translate this general framework into an explicit system dynamics model of the interaction of physiological loss, stressors and endogenous responses to produce a familiar variety of trajectories of functional ability over the life courses. Simulation experiments were implemented for both a 30-month duration with only one major stressor; and for the life course with an initial major stressor and subsequent stressors determined by the level of functional ability. For both contexts, variations in the few parameters in the scenarios led to a realistic range of trajectories of function over time.
Social Sciences, Mathematical Methods
Business & Economics
Mathematical Methods In Social Sciences
Published Version (Please cite this version)10.1002/sdr.1611
Publication InfoMatchar, David B; Ansah, John P; Koh, Victoria; & Whitson, Heather E (2018). Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience. System dynamics review, 34(4). pp. 481-502. 10.1002/sdr.1611. Retrieved from https://hdl.handle.net/10161/22797.
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David Bruce Matchar
Professor of Medicine
My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention. Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analy
Heather Elizabeth Whitson
Professor of Medicine
Dr. Whitson's research is focused on improving care options and resilience for people with multiple chronic conditions. In particular, she has interest and expertise related to the link between age-related changes in the eye and brain (e.g., How does late-life vision loss impact the aging brain or cognitive outcomes? Is Alzheimer's disease associated with distinctive changes in the retina, and could such changes help diagnose Alzheimer's disease early in its course?). Dr. Whits
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