Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience.
Abstract
Understanding the factors that influence functional ability over the life course is
integral to identifying clinical and public health policies to facilitate successful
aging. The World Health Organization has advocated a conceptual framework to clarify
the policy discussion. We have sought to translate this general framework into an
explicit system dynamics model of the interaction of physiological loss, stressors
and endogenous responses to produce a familiar variety of trajectories of functional
ability over the life courses. Simulation experiments were implemented for both a
30-month duration with only one major stressor; and for the life course with an initial
major stressor and subsequent stressors determined by the level of functional ability.
For both contexts, variations in the few parameters in the scenarios led to a realistic
range of trajectories of function over time.
Type
Journal articleSubject
Social SciencesManagement
Social Sciences, Mathematical Methods
Business & Economics
Mathematical Methods In Social Sciences
SYSTEM DYNAMICS
PSYCHOMETRIC PROPERTIES
HEALTH-SERVICES
CARE
OPTIMISM
FRAILTY
POLICY
PERSPECTIVE
PERFORMANCE
POPULATION
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https://hdl.handle.net/10161/22797Published Version (Please cite this version)
10.1002/sdr.1611Publication Info
Matchar, David B; Ansah, John P; Koh, Victoria; & Whitson, Heather E (2018). Trajectories of functional ability over the life course: a conceptual model of the
interaction of stressor-induced functional loss and resilience. System dynamics review, 34(4). pp. 481-502. 10.1002/sdr.1611. Retrieved from https://hdl.handle.net/10161/22797.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
David Bruce Matchar
Professor of Medicine
My research relates to clinical practice improvement - from the development of clinical
policies to their implementation in real world clinical settings. Most recently my
major content focus has been cerebrovascular disease. Other major clinical areas in
which I work include the range of disabling neurological conditions, cardiovascular
disease, and cancer prevention. Notable features of my work are: (1) reliance on
analytic strategies such as meta-analysis, simulation, decision analy
Heather Elizabeth Whitson
Professor of Medicine
Dr. Whitson's research is focused on improving care options and resilience for people
with multiple chronic conditions. In particular, she has interest and expertise related
to the link between age-related changes in the eye and brain (e.g., How does late-life
vision loss impact the aging brain or cognitive outcomes? Is Alzheimer's disease
associated with distinctive changes in the retina, and could such changes help diagnose
Alzheimer's disease early in its course?). Dr. Whits
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