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Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19.

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Date
2021-04-13
Authors
Yu, Chen
Littleton, Sejiro
Giroux, Nicholas S
Mathew, Rose
Ding, Shengli
Kalnitsky, Joan
Yang, Yuchen
Petzold, Elizabeth
Chung, Hong A
Rivera, Grecia O
Rotstein, Tomer
Xi, Rui
Ko, Emily R
Tsalik, Ephraim L
Sempowski, Gregory D
Denny, Thomas N
Burke, Thomas W
McClain, Micah T
Woods, Christopher W
Shen, Xiling
Saban, Daniel R
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(21 total)
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Abstract
Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral blood mononuclear cells from confirmed COVID-19 inpatients and outpatients, uninfected close contacts, and healthy controls for 36-color flow cytometry and single cell RNA-sequencing. Our results revealed a pronounced reduction of circulating mucosal associated invariant T (MAIT) cells in infected females. Integration of published COVID-19 airway tissue datasets implicate that this reduction represented a major wave of MAIT cell extravasation during early infection in females. Moreover, female MAIT cells possessed an immunologically active gene signature, whereas male counterparts were pro-apoptotic. Collectively, our findings uncover a female-specific protective MAIT profile, potentially shedding light on reduced COVID-19 susceptibility in females.
Type
Journal article
Subject
IL-7
SARS-CoV-2
apoptosis
innate immunity
monocyte
Permalink
https://hdl.handle.net/10161/22841
Published Version (Please cite this version)
10.1016/j.medj.2021.04.008
Publication Info
Yu, Chen; Littleton, Sejiro; Giroux, Nicholas S; Mathew, Rose; Ding, Shengli; Kalnitsky, Joan; ... Saban, Daniel R (2021). Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19. Med (New York, N.Y.). 10.1016/j.medj.2021.04.008. Retrieved from https://hdl.handle.net/10161/22841.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Burke

Thomas Burke

Manager, Systems Project
Denny

Thomas Norton Denny

Professor in Medicine
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine Institute (DHVI), Associate Dean for Duke Research and Discovery @RTP, and a Professor of Medicine in the Department of Medicine at Duke University Medical Center. He is also an Affiliate Member of the Duke Global Health Institute. Previously, he served on the Health Sector Advisory Council of the Duke University Fuquay School of Business. Prior to joining Duke, he was an Associate Professor of Pathology, Labo
Ko

Emily Ray Ko

Assistant Professor of Medicine
Clinical and translational research, COVID-19 therapeutics, clinical biomarkers for infectious disease.
McClain

Micah Thomas McClain

Associate Professor of Medicine
Saban

Daniel Raphael Saban

Associate Professor of Ophthalmology
My broad research interests are the cellular and molecular mechanisms that contribute to pathogenic immunity in ophthalmic disease and vision loss. My studies are currently focused on dendritic cells (DC), a unique leukocyte population of antigen presenting cells required for both initiating and determining the type of immune response generated. These cells contribute to the maintenance of health versus immunity in ocular disease. I am currently investigating the r
Sempowski

Gregory David Sempowski

Professor in Medicine
Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. H
Shen

Xiling Shen

Adjunct Professor in the Department of Pathology
Dr. Shen’s research interests lie at precision medicine and systems biology. His lab integrates engineering, computational and biological techniques to study cancer, stem cells, microbiota and the nervous system in the gut. This multidisciplinary work has been instrumental in initiating several translational clinical trials in precision therapy. He is the director of the Woo Center for Big Data and Precision Health (DAP) and a core member of the Center for Genomics and Computational Biolog
Tsalik

Ephraim Tsalik

Adjunct Associate Professor in the Department of Medicine
My research at Duke has focused on understanding the dynamic between host and pathogen so as to discover and develop host-response markers that can diagnose and predict health and disease.  This new and evolving approach to diagnosing illness has the potential to significantly impact individual as well as public health considering the rise of antibiotic resistance. With any potential infectious disease diagnosis, it is difficult, if not impossible, to determine at the time of pre
Woods

Christopher Wildrick Woods

Professor of Medicine
1. Emerging Infections 2. Global Health 3. Epidemiology of infectious diseases 4. Clinical microbiology and diagnostics 5. Bioterrorism Preparedness 6. Surveillance for communicable diseases 7. Antimicrobial resistance
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