Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.
Abstract
<h4>Background</h4>Cognitive dysfunction can be a long-term complication following
subarachnoid hemorrhage (SAH). Preclinical models have been variously characterized
to emulate this disorder. This study was designed to directly compare long-term cognitive
deficits in the context of similar levels of insult severity in the cisterna magna
double-blood (DB) injection versus prechiasmatic blood (PB) injection SAH models.<h4>Methods</h4>Pilot
work identified blood injectate volumes necessary to provide similar mortality rates
(20-25 %). Rats were then randomly assigned to DB or PB insults. Saline injection
and naïve rats were used as controls. Functional and cognitive outcome was assessed
over 35 days.<h4>Results</h4>DB and PB caused similar transient rotarod deficits.
PB rats exhibited decreased anxiety behavior on the elevated plus maze, while anxiety
was increased in DB. DB and PB caused differential deficits in the novel object recognition
and novel object location tasks. Morris water maze performance was similarly altered
in both models (decreased escape latency and increased swimming speed). SAH caused
histologic damage in the medial prefrontal cortex, perirhinal cortex, and hippocampal
CA1, although severity of injury in the respective regions differed between DB and
PB.<h4>Conclusion</h4>Both SAH models caused long-term cognitive deficits in the context
of similar insult severity. Cognitive deficits differed between the two models, as
did distribution of histologic injury. Each model offers unique properties and both
models may be useful for study of SAH-induced cognitive deficits.
Type
Journal articleSubject
AnimalsRats
Rats, Wistar
Subarachnoid Hemorrhage
Disease Models, Animal
Behavior, Animal
Maze Learning
Male
Cognitive Dysfunction
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https://hdl.handle.net/10161/23258Published Version (Please cite this version)
10.1007/s12028-016-0250-1Publication Info
Sasaki, Toshihiro; Hoffmann, Ulrike; Kobayashi, Motomu; Sheng, Huaxin; Ennaceur, Abdelkader;
Lombard, Frederick W; & Warner, David S (2016). Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. Neurocritical care, 25(2). pp. 293-305. 10.1007/s12028-016-0250-1. Retrieved from https://hdl.handle.net/10161/23258.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Ulrike Hoffmann
Assistant Professor of Anesthesiology
Frederick Wilhelm Lombard
Adjunct Associate Professor in the Department of Anesthesiology
1. Animal models of Subarachnoid Hemorrhage (SAH) induced Cerebral Vasospasm 2. Pathogenesis
of Cerebral Vasospasm following SAH 3. Translational Research in SAH 4. Long-term
Outcome following Endovascular Coiling of Unruptured Cerebral Aneurysms
Huaxin Sheng
Associate Professor in Anesthesiology
We have successfully developed various rodent models of brain and spinal cord injuries
in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma,
subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia and compression
injury. We also established cardiac arrest and hemorrhagic shock models for studying
multiple organ dysfunction. Our current studies focus on two projects. One is to
examine the efficacy of catalytic antioxidant in treating cerebral is
David Samuel Warner
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Humans may sustain a variety of forms of acute central nervous system injury including
ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection
Laboratories is dedicated to examining the pathophysiology of acute brain and spinal
cord injury with particular reference to disease states managed in the perioperative
or neurointensive care environments. Rodent recovery models of cerebral ischemia,
traumatic brain injury, cardiopulmonary bypass, subarachnoid he
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