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Anesthesia in Experimental Stroke Research.

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Date
2016-10
Authors
Hoffmann, Ulrike
Sheng, Huaxin
Ayata, Cenk
Warner, David S
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Abstract
Anesthetics have enabled major advances in development of experimental models of human stroke. Yet, their profound pharmacologic effects on neural function can confound the interpretation of experimental stroke research. Anesthetics have species-, drug-, and dose-specific effects on cerebral blood flow and metabolism, neurovascular coupling, autoregulation, ischemic depolarizations, excitotoxicity, inflammation, neural networks, and numerous molecular pathways relevant for stroke outcome. Both preconditioning and postconditioning properties have been described. Anesthetics also modulate systemic arterial blood pressure, lung ventilation, and thermoregulation, all of which may interact with the ischemic insult as well as the therapeutic interventions. These confounds present a dilemma. Here, we provide an overview of the anesthetic mechanisms of action and molecular and physiologic effects on factors relevant to stroke outcomes that can guide the choice and optimization of the anesthetic regimen in experimental stroke.
Type
Journal article
Subject
Animals
Humans
Brain Ischemia
Disease Models, Animal
Nitrous Oxide
Anesthetics
Ischemic Preconditioning
Anesthesia
Homeostasis
Cerebrovascular Circulation
Stroke
Permalink
https://hdl.handle.net/10161/23262
Published Version (Please cite this version)
10.1007/s12975-016-0491-5
Publication Info
Hoffmann, Ulrike; Sheng, Huaxin; Ayata, Cenk; & Warner, David S (2016). Anesthesia in Experimental Stroke Research. Translational stroke research, 7(5). pp. 358-367. 10.1007/s12975-016-0491-5. Retrieved from https://hdl.handle.net/10161/23262.
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Scholars@Duke

Ulrike Hoffmann

Assistant Professor of Anesthesiology
Sheng

Huaxin Sheng

Associate Professor in Anesthesiology
We have successfully developed various rodent models of brain and spinal cord injuries in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma, subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia and compression injury. We also established cardiac arrest and hemorrhagic shock models for studying multiple organ dysfunction.  Our current studies focus on two projects. One is to examine the efficacy of catalytic antioxidant in treating cerebral is
Warner

David Samuel Warner

Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Humans may sustain a variety of forms of acute central nervous system injury including ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection Laboratories is dedicated to examining the pathophysiology of acute brain and spinal cord injury with particular reference to disease states managed in the perioperative or neurointensive care environments. Rodent recovery models of cerebral ischemia, traumatic brain injury, cardiopulmonary bypass, subarachnoid he
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
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