Anesthesia in Experimental Stroke Research.
Abstract
Anesthetics have enabled major advances in development of experimental models of human
stroke. Yet, their profound pharmacologic effects on neural function can confound
the interpretation of experimental stroke research. Anesthetics have species-, drug-,
and dose-specific effects on cerebral blood flow and metabolism, neurovascular coupling,
autoregulation, ischemic depolarizations, excitotoxicity, inflammation, neural networks,
and numerous molecular pathways relevant for stroke outcome. Both preconditioning
and postconditioning properties have been described. Anesthetics also modulate systemic
arterial blood pressure, lung ventilation, and thermoregulation, all of which may
interact with the ischemic insult as well as the therapeutic interventions. These
confounds present a dilemma. Here, we provide an overview of the anesthetic mechanisms
of action and molecular and physiologic effects on factors relevant to stroke outcomes
that can guide the choice and optimization of the anesthetic regimen in experimental
stroke.
Type
Journal articleSubject
AnimalsHumans
Brain Ischemia
Disease Models, Animal
Nitrous Oxide
Anesthetics
Ischemic Preconditioning
Anesthesia
Homeostasis
Cerebrovascular Circulation
Stroke
Permalink
https://hdl.handle.net/10161/23262Published Version (Please cite this version)
10.1007/s12975-016-0491-5Publication Info
Hoffmann, Ulrike; Sheng, Huaxin; Ayata, Cenk; & Warner, David S (2016). Anesthesia in Experimental Stroke Research. Translational stroke research, 7(5). pp. 358-367. 10.1007/s12975-016-0491-5. Retrieved from https://hdl.handle.net/10161/23262.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Ulrike Hoffmann
Assistant Professor of Anesthesiology
Huaxin Sheng
Associate Professor in Anesthesiology
We have successfully developed various rodent models of brain and spinal cord injuries
in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma,
subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia and compression
injury. We also established cardiac arrest and hemorrhagic shock models for studying
multiple organ dysfunction. Our current studies focus on two projects. One is to
examine the efficacy of catalytic antioxidant in treating cerebral is
David Samuel Warner
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Humans may sustain a variety of forms of acute central nervous system injury including
ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection
Laboratories is dedicated to examining the pathophysiology of acute brain and spinal
cord injury with particular reference to disease states managed in the perioperative
or neurointensive care environments. Rodent recovery models of cerebral ischemia,
traumatic brain injury, cardiopulmonary bypass, subarachnoid he
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info