The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass.
Abstract
<h4>Objective</h4>Higher mean arterial pressure during cardiopulmonary bypass may
improve cerebral outcome associated with cerebral air embolism by increasing emboli
clearance and collateral flow to salvage the ischemic penumbra. However, this may
come at the expense of increased delivery of embolic load. This study was designed
to investigate the influence of mean arterial pressures on cerebral functional and
histologic outcome after cerebral air embolism during cardiopulmonary bypass in an
established rat model.<h4>Methods</h4>Male Sprague-Dawley rats were exposed to 90
minutes of normothermic cardiopulmonary bypass with 10 cerebral air embolisms (0.3
μL/bolus) injected repetitively. Rats were randomized to 3 groups (n = 10, each) that
differed in mean arterial pressure management during cardiopulmonary bypass: 50 mm
Hg (low mean arterial pressure), 60 to 70 mm Hg (standard mean arterial pressure),
and 80 mm Hg (high mean arterial pressure). Neurologic score was assessed on postoperative
days 3 and 7 when cerebral infarct volumes were determined. Cognitive function was
determined with the Morris water maze test beginning on postoperative day 3 and continuing
to postoperative day 7.<h4>Results</h4>Neurologic score was better in high and standard
mean arterial pressure groups versus low mean arterial pressure groups. High mean
arterial pressure resulted in shorter water maze latencies compared with standard
and low mean arterial pressure on postoperative days 6 and 7. Total infarct volume
and number of infarct areas were not different among groups.<h4>Conclusions</h4>The
use of higher mean arterial pressure during cardiopulmonary bypass in a rat model
of cerebral air embolism conveyed beneficial effects on functional cerebral outcome
with no apparent disadvantage of increased delivery of embolic load. Maintaining higher
perfusion pressures in situations of increased cerebral embolic load may be considered
as a collateral therapeutic strategy.
Type
Journal articleSubject
BrainAnimals
Rats
Rats, Sprague-Dawley
Intracranial Embolism
Embolism, Air
Cardiopulmonary Bypass
Blood Pressure
Male
Permalink
https://hdl.handle.net/10161/23290Published Version (Please cite this version)
10.1016/j.jtcvs.2010.11.036Publication Info
Qing, M; Shim, JK; Grocott, HP; Sheng, H; Mathew, JP; & Mackensen, GB (2011). The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism
during cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery, 142(2). pp. 424-429. 10.1016/j.jtcvs.2010.11.036. Retrieved from https://hdl.handle.net/10161/23290.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Joseph P. Mathew
Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Current research interests include:1. The relationship between white matter patency,
functional connectivity (fMRI) and neurocognitive function following cardiac surgery.2.
The relationship between global and regional cortical beta-amyloid deposition and
postoperative cognitive decline.3. The effect of lidocaine infusion upon neurocognitive
function following cardiac surgery.4. The association between genotype and outcome
after cardiac surgery.5. Atrial fibrillation
Huaxin Sheng
Associate Professor in Anesthesiology
We have successfully developed various rodent models of brain and spinal cord injuries
in our lab, such as focal cerebral ischemia, global cerebral ischemia, head trauma,
subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord ischemia and compression
injury. We also established cardiac arrest and hemorrhagic shock models for studying
multiple organ dysfunction. Our current studies focus on two projects. One is to
examine the efficacy of catalytic antioxidant in treating cerebral is
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info