Detection of Atrial Fibrillation After Central Retinal Artery Occlusion
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<jats:sec> <jats:title>Background:</jats:title> <jats:p>Central retinal artery occlusion (CRAO) causes sudden, irreversible blindness and is a form of acute ischemic stroke. In this study, we sought to determine the proportion of patients in whom atrial fibrillation (AF) is detected by extended cardiac monitoring after CRAO.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We performed a retrospective, observational cohort study using data from the Optum deidentified electronic health record of 30.8 million people cross-referenced with the Medtronic CareLink database of 2.7 million people with cardiac monitoring devices in situ. We enrolled patients in 3 groups: (1) CRAO, (2) cerebral ischemic stroke, and (3) age-, sex-, and comorbidity-matched controls. The primary end point was the detection of new AF (defined as ≥2 minutes of AF detected on a cardiac monitoring device).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>We reviewed 884 431 patient records in common between the two databases to identify 100 patients with CRAO, 6559 with ischemic stroke, and 1000 matched controls. After CRAO, the cumulative incidence of new AF at 2 years was 49.6% (95% CI, 37.4%–61.7%). Patients with CRAO had a higher rate of AF than controls (hazard ratio, 1.64 [95% CI, 1.17–2.31]) and a comparable rate to patients with stroke (hazard ratio, 1.01 [95% CI, 0.75–1.36]). CRAO was associated with a higher incidence of new stroke compared with matched controls (hazard ratio, 2.85 [95% CI, 1.29–6.29]).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>The rate of AF detection after CRAO is higher than that seen in age-, sex-, and comorbidity-matched controls and comparable to that seen after ischemic cerebral stroke. Paroxysmal AF should be considered as part of the differential etiology of CRAO, and those patients may benefit from long-term cardiac monitoring.</jats:p> </jats:sec>
Published Version (Please cite this version)10.1161/strokeaha.120.033934
Publication InfoMac Grory, Brian; Landman, Sean R; Ziegler, Paul D; Boisvert, Chantal J; Flood, Shane P; Stretz, Christoph; ... Yaghi, Shadi (n.d.). Detection of Atrial Fibrillation After Central Retinal Artery Occlusion. Stroke. 10.1161/strokeaha.120.033934. Retrieved from https://hdl.handle.net/10161/23377.
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Associate Professor of Ophthalmology
Dr. Chantal Boisvert, Associate Professor of Ophthalmology at Duke University Eye Center, received her medical degree from Laval University School of Medicine and completed her residency in ophthalmology at the University of Montreal Hospitals. She then completed two fellowships, one in pediatric ophthalmology and strabismus at UCSD Shiley Eye Center, and the other in neuro-ophthalmology at USC Doheny Eye Center. Prior to joining Duke, she was Associate Clinical Prof
Professor of Neurology
Assistant Professor of Neurology
Associate Professor in Neurology
Dr. Xian is an Associate Professor of Neurology and Medicine at the Duke University Medical Center and Duke Clinical Research Institute. He received his Medical Degree from Beijing Medical University (Peking University Health Science Center) and completed an Internal Medicine Residency and Cardiology Fellowship at Peking University People’s Hospital, and Fuwai Hospital, Peking Union Medical College. Dr. Xian’s research is dedicated to improving health care quality and outcomes in
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