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Validation of the Finnish Version of the Unified Dyskinesia Rating Scale.

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Date
2021-07-14
Authors
Kaasinen, Valtteri
Scheperjans, Filip
Kärppä, Mikko
Korpela, Jaana
Brück, Anna
Sipilä, Jussi OT
Joutsa, Juho
Järvelä, Juha
Eerola-Rautio, Johanna
Martikainen, Mika H
Airaksinen, Katja
Stebbins, Glenn T
Martinez-Martin, Pablo
Goetz, Christopher G
Lin, Jeffrey
Luo, Sheng
Pekkonen, Eero
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(17 total)
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Abstract
<h4>Introduction</h4>The Unified Dyskinesia Rating Scale (UDysRS) was developed to provide a comprehensive rating tool of dyskinesia in Parkinson's disease (PD). Because dyskinesia therapy trials involve multicenter studies, having a scale that is validated in multiple non-English languages is pivotal to international efforts to treat dyskinesia. The aim of the present study was to organize and perform an independent validation of the UDysRS Finnish version.<h4>Methods</h4>The UDysRS was translated into Finnish and then back-translated into English using 2 independent teams. Cognitive pretesting was conducted on the Finnish version and required modifications to the structure or wording of the translation. The final Finnish version was administered to 250 PD patients whose native language is Finnish. The data were analyzed to assess the confirmatory factor structure to the Spanish UDysRS (the reference standard). Secondary analyses included an exploratory factor analysis (EFA), independent of the reference standard.<h4>Results</h4>The comparative fit index (CFI), in comparison with the reference standard factor structure, was 0.963 for Finnish. In the EFA, where variability from sample to sample is expected, isolated item differences of factor structure were found between the Finnish and Reference Standard versions of the UDysRS. These subtle differences may relate to differences in sample composition or variations in disease status.<h4>Conclusion</h4>The overall factor structure of the Finnish version was consistent with that of the reference standard, and it can be designated as the official version of the UDysRS for Finnish speaking populations.
Type
Journal article
Subject
Dyskinesia
Parkinson’s disease
Unified dyskinesia rating scale
Permalink
https://hdl.handle.net/10161/23472
Published Version (Please cite this version)
10.1159/000517369
Publication Info
Kaasinen, Valtteri; Scheperjans, Filip; Kärppä, Mikko; Korpela, Jaana; Brück, Anna; Sipilä, Jussi OT; ... Pekkonen, Eero (2021). Validation of the Finnish Version of the Unified Dyskinesia Rating Scale. European neurology. pp. 1-6. 10.1159/000517369. Retrieved from https://hdl.handle.net/10161/23472.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Luo

Sheng Luo

Professor of Biostatistics & Bioinformatics
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