Retrospective cohort study of changes in estimated glomerular filtration rate for patients prescribed a low carb diet.
Abstract
<h4>Purpose of review</h4>Obesity and diabetes contribute to chronic kidney disease
(CKD) and accelerate the loss of kidney function. Low carbohydrate diets (LCDs) are
associated with weight loss and improved diabetes control. Compared to the typical
Western diet, LCDs contain more protein, so individuals with CKD are not included
in studies of LCDs. Therefore, there are no studies of LCDs for weight loss and their
effects on kidney function.<h4>Recent findings</h4>Obesity, hyperglycemia, and hyperinsulinemia
can be detrimental to kidney function. LCDs may improve kidney function in patients
with obesity and diabetes because they are associated with weight loss, improve blood
sugar control, and decrease endogenous insulin production and exogenous insulin requirements.<h4>Summary</h4>In
this study, for patients with mildly reduced and moderately to severely reduced kidney
function who were prescribed an LCD, their estimated glomerular filtration rate (eGFR)
was either unchanged or improved. For those with normal or elevated eGFR, their kidney
function was slightly decreased. For those without diabetes, greater weight loss was
associated with improved eGFR. Future studies should prospectively measure low carbohydrate
dietary adherence and physical activity and directly measure changes in GFR and albuminuria
for participants with CKD before and during that diet.
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Journal articlePermalink
https://hdl.handle.net/10161/23690Published Version (Please cite this version)
10.1097/med.0000000000000673Publication Info
Mitchell, Nia S; Batch, Bryan C; & Tyson, Crystal C (2021). Retrospective cohort study of changes in estimated glomerular filtration rate for
patients prescribed a low carb diet. Current opinion in endocrinology, diabetes, and obesity, Publish Ahead of Print. 10.1097/med.0000000000000673. Retrieved from https://hdl.handle.net/10161/23690.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Bryan Courtney Batch
Associate Professor of Medicine
Type 2 Diabetes, Obesity/Overweight, Behavior change, Non-pharmacologic intervention,
Health disparities
Nia Schwann Mitchell
Associate Professor of Medicine
Crystal Cenell Tyson
Assistant Professor of Medicine
As a board-certified nephrologist and a certified clinical hypertension specialist
(ASH-SCH), I take care of patients with kidney disorders and/or high blood pressure.
Patients with chronic kidney disease and high blood pressure have an increased risk
for developing complications of cardiovascular disease, such as heart attacks, congestive
heart failure, strokes, kidney failure requiring dialysis or a kidney transplant,
and a shortened lifespan. My clinical focus is to slow the progression of
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