The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy.
Abstract
The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose
(FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability
of standardized uptake values (SUVs). The Profile provides two complementary claims
on the precision of SUV measurements. First, tumor glycolytic activity as reflected
by the maximum SUV (SUVmax) is measurable from FDG PET/CT with a within-subject coefficient of variation of
10%-12%. Second, a measured increase in SUVmax of 39% or more, or a decrease of 28% or more, indicates that a true change has occurred
with 95% confidence. Two applicable use cases are clinical trials and following individual
patients in clinical practice. Other components of the Profile address the protocols
and conformance standards considered necessary to achieve the performance claim. The
Profile is intended for use by a broad audience; applications can range from discovery
science through clinical trials to clinical practice. The goal of this report is to
provide a rationale and overview of the FDG PET/CT Profile claims as well as its context,
and to outline future needs and potential developments.
Type
Journal articleSubject
HumansNeoplasms
Fluorodeoxyglucose F18
Image Interpretation, Computer-Assisted
Neoplasm Staging
Treatment Outcome
Biomarkers, Tumor
Positron Emission Tomography Computed Tomography
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https://hdl.handle.net/10161/23702Published Version (Please cite this version)
10.1148/radiol.2019191882Publication Info
Kinahan, Paul E; Perlman, Eric S; Sunderland, John J; Subramaniam, Rathan; Subramaniam,
Rathan; Wollenweber, Scott D; ... Wahl, Richard L (2020). The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer
Therapy. Radiology, 294(3). pp. 647-657. 10.1148/radiol.2019191882. Retrieved from https://hdl.handle.net/10161/23702.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Rathan Markandan Subramaniam
Adjunct Professor in the Department of Radiology
I am a Neuroradiologist and Nuclear Medicine physician with academic interest in cancer
imaging, epigenetics, cancer care delivery, focused on head and neck cancer and a
co-chair (imaging) of multi-institutional therapeutic clinical trials in head and
neck cancer.
Rathan Markandan Subramaniam
Adjunct Professor in the Department of Radiology
I am a Neuroradiologist and Nuclear Medicine physician with academic interest in cancer
imaging, epigenetics, cancer care delivery, focused on head and neck cancer and a
co-chair (imaging) of multi-institutional therapeutic clinical trials in head and
neck cancer.
Timothy Garvey Turkington
Associate Professor in Radiology
My work focuses on PET imaging physics, including instrumentation, reconstruction,
and image processing. We're working toward more quantitatively accurate PET, reduction
in scan times and radiation dose in PET/CT, novel imaging devices for PET (and SPECT),
and application of PET to more clinical and research needs. Positron Emission Tomography
is now in widespread use as a clinical tool for oncology, neurology, and cardiology,
and continues to be used as a research tool in thes
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