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Evaluation of high-perimeter electrode designs for deep brain stimulation.

dc.contributor.author Howell, Bryan
dc.contributor.author Grill, Warren M
dc.date.accessioned 2021-09-28T18:54:08Z
dc.date.available 2021-09-28T18:54:08Z
dc.date.issued 2014-08
dc.identifier.issn 1741-2560
dc.identifier.issn 1741-2552
dc.identifier.uri https://hdl.handle.net/10161/23856
dc.description.abstract <h4>Objective</h4>Deep brain stimulation (DBS) is an effective treatment for movement disorders and a promising therapy for treating epilepsy and psychiatric disorders. Despite its clinical success, complications including infections and mis-programing following surgical replacement of the battery-powered implantable pulse generator adversely impact the safety profile of this therapy. We sought to decrease power consumption and extend battery life by modifying the electrode geometry to increase stimulation efficiency. The specific goal of this study was to determine whether electrode contact perimeter or area had a greater effect on increasing stimulation efficiency.<h4>Approach</h4>Finite-element method (FEM) models of eight prototype electrode designs were used to calculate the electrode access resistance, and the FEM models were coupled with cable models of passing axons to quantify stimulation efficiency. We also measured in vitro the electrical properties of the prototype electrode designs and measured in vivo the stimulation efficiency following acute implantation in anesthetized cats.<h4>Main results</h4>Area had a greater effect than perimeter on altering the electrode access resistance; electrode (access or dynamic) resistance alone did not predict stimulation efficiency because efficiency was dependent on the shape of the potential distribution in the tissue; and, quantitative assessment of stimulation efficiency required consideration of the effects of the electrode-tissue interface impedance.<h4>Significance</h4>These results advance understanding of the features of electrode geometry that are important for designing the next generation of efficient DBS electrodes.
dc.language eng
dc.publisher IOP Publishing
dc.relation.ispartof Journal of neural engineering
dc.relation.isversionof 10.1088/1741-2560/11/4/046026
dc.subject Axons
dc.subject Animals
dc.subject Cats
dc.subject Electromyography
dc.subject Deep Brain Stimulation
dc.subject Equipment Design
dc.subject Electrodes
dc.subject Algorithms
dc.subject Finite Element Analysis
dc.subject Models, Neurological
dc.subject Computer Simulation
dc.title Evaluation of high-perimeter electrode designs for deep brain stimulation.
dc.type Journal article
duke.contributor.id Howell, Bryan|0503702
duke.contributor.id Grill, Warren M|0315993
dc.date.updated 2021-09-28T18:54:08Z
pubs.begin-page 046026
pubs.issue 4
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Electrical and Computer Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Duke Science & Society
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Neurosurgery
pubs.organisational-group Duke
pubs.organisational-group Basic Science Departments
pubs.organisational-group School of Medicine
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 11
duke.contributor.orcid Howell, Bryan|0000-0002-3329-8478


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