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Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

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Date
2021-11-26
Authors
Zafferani, Martina
Haddad, Christina
Luo, Le
Davila-Calderon, Jesse
Chiu, Liang-Yuan
Mugisha, Christian Shema
Monaghan, Adeline G
Kennedy, Andrew A
Yesselman, Joseph D
Gifford, Robert J
Tai, Andrew W
Kutluay, Sebla B
Li, Mei-Ling
Brewer, Gary
Tolbert, Blanton S
Hargrove, Amanda E
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(16 total)
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Journal article
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https://hdl.handle.net/10161/24025
Published Version (Please cite this version)
10.1126/sciadv.abl6096
Publication Info
Zafferani, Martina; Haddad, Christina; Luo, Le; Davila-Calderon, Jesse; Chiu, Liang-Yuan; Mugisha, Christian Shema; ... Hargrove, Amanda E (2021). Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures. Science Advances, 7(48). 10.1126/sciadv.abl6096. Retrieved from https://hdl.handle.net/10161/24025.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Hargrove

Amanda Hargrove

Professor of Chemistry
The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are t
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