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Characteristics of abdominal vein thrombosis in children and adults.

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Date
2013-04
Authors
Landi, Daniel
Beckman, Michele G
Shah, Nirmish R
Bockenstedt, Paula
Grant, Althea M
Heit, John A
Key, Nigel S
Kulkarni, Roshni
Manco-Johnson, Marilyn
Moll, Stephan
Philipp, Claire S
Andersen, Judith C
Ortel, Thomas L
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(13 total)
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Abstract
The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospectively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal VT, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.
Type
Journal article
Subject
Abdomen
Adolescent
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Body Mass Index
Chi-Square Distribution
Child
Child, Preschool
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Logistic Models
Lower Extremity
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Prognosis
Prospective Studies
Registries
Risk Factors
Sex Factors
Thrombophilia
United States
Vena Cava, Inferior
Venous Thrombosis
Wounds and Injuries
Young Adult
Permalink
https://hdl.handle.net/10161/24074
Published Version (Please cite this version)
10.1160/TH12-08-0568
Publication Info
Landi, Daniel; Beckman, Michele G; Shah, Nirmish R; Bockenstedt, Paula; Grant, Althea M; Heit, John A; ... Ortel, Thomas L (2013). Characteristics of abdominal vein thrombosis in children and adults. Thromb Haemost, 109(4). pp. 625-632. 10.1160/TH12-08-0568. Retrieved from https://hdl.handle.net/10161/24074.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Landi

Daniel Bryce Landi

Assistant Professor of Pediatrics
Ortel

Thomas Lee Ortel

Chief, Division of Hematology in the Department of Medicine
My research program investigates the molecular mechanisms whereby various congenital and acquired abnormalities result in ‘dysfunctional’ hemostasis (i.e., hemorrhage or thrombosis) to better understand the molecular mechanisms and interactions that are necessary for normal hemostasis. We are particularly interested in the mechanisms whereby antibodies and other inhibitors can interfere with normal hemostatic mechanisms. Several projects extensively overlap and focus on the as
Shah

Nirmish Ramesh Shah

Associate Professor of Medicine
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