Characteristics of abdominal vein thrombosis in children and adults.
Abstract
The demographic and clinical characteristics of adults and children with lower extremity
deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with
abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of
an underlying prothrombotic state, and its presence in the setting of known disease
might have prognostic implications different from LE DVT/PE. This study describes
clinical presentations of abdominal VT compared to LE DVT/PE in adults and children.
We analysed prospectively-collected data from consecutive consenting patients enrolled
in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis
and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic
and clinical characteristics of adults and children with abdominal VT. Both adults
and children with abdominal VT tended to be younger and have a lower body mass index
(BMI) than those with LE DVT/PE. Of patients with abdominal VT, children were more
likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous
thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while
the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children
with abdominal VT were more likely to have diagnosed inherited thrombophilia, while
trauma was more common in children with LE DVT/PE. In conclusion, both children and
adults with abdominal VT were younger with a lower BMI than those with LE DVT/PE.
Significant differences exist between children and adults in respect to abdominal
VT compared to LE DVT/PE.
Type
Journal articleSubject
AbdomenAdolescent
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Body Mass Index
Chi-Square Distribution
Child
Child, Preschool
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Logistic Models
Lower Extremity
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Prognosis
Prospective Studies
Registries
Risk Factors
Sex Factors
Thrombophilia
United States
Vena Cava, Inferior
Venous Thrombosis
Wounds and Injuries
Young Adult
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https://hdl.handle.net/10161/24074Published Version (Please cite this version)
10.1160/TH12-08-0568Publication Info
Landi, Daniel; Beckman, Michele G; Shah, Nirmish R; Bockenstedt, Paula; Grant, Althea
M; Heit, John A; ... Ortel, Thomas L (2013). Characteristics of abdominal vein thrombosis in children and adults. Thromb Haemost, 109(4). pp. 625-632. 10.1160/TH12-08-0568. Retrieved from https://hdl.handle.net/10161/24074.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Daniel Bryce Landi
Assistant Professor of Pediatrics
Thomas Lee Ortel
Chief, Division of Hematology in the Department of Medicine
My research program investigates the molecular mechanisms whereby various congenital
and acquired abnormalities result in ‘dysfunctional’ hemostasis (i.e.,
hemorrhage or thrombosis) to better understand the molecular mechanisms and interactions
that are necessary for normal hemostasis. We are particularly interested in the mechanisms
whereby antibodies and other inhibitors can interfere with normal hemostatic mechanisms.
Several projects extensively overlap and focus on the as
Nirmish Ramesh Shah
Associate Professor of Medicine
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